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Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone

https://asahikawa-med.repo.nii.ac.jp/records/714
https://asahikawa-med.repo.nii.ac.jp/records/714
d38f8835-be31-468a-9a1f-780335b3f14f
名前 / ファイル ライセンス アクション
894.pdf 894.pdf (188.9 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2008-03-28
タイトル
タイトル Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 神山, 直也

× 神山, 直也

神山, 直也

ja-Kana カミヤマ, ナオヤ

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Takagi, S

× Takagi, S

Takagi, S

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Yamamoto, C

× Yamamoto, C

Yamamoto, C

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Kudo, T

× Kudo, T

Kudo, T

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Nakagawa, T

× Nakagawa, T

Nakagawa, T

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Takahashi, M

× Takahashi, M

Takahashi, M

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Nakanishi, K

× Nakanishi, K

Nakanishi, K

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Todo, S

× Todo, S

Todo, S

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Iseki, K

× Iseki, K

Iseki, K

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著者 ローマ字
Kamiyama, Naoya
書誌情報 ANTICANCER RESEARCH

巻 26, 号 2A, p. 885-888, 発行日 2006-01-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0250-7005
リンクURL
内容記述タイプ Other
内容記述 http://www.ncbi.nlm.nih.gov/pubmed?term=Expression%20of%20ABC%20transporters%20in%20human%20hepatocyte%20carcinoma%20cells%20with%20cross-resistance%20to%20epirubicin%20and%20mitoxantrone | http://www.ncbi.nlm.nih.gov/pubmed?term=Expression%20of%20ABC%20transporters%20in%20human%20hepatocyte%20carcinoma%20cells%20with%20cross-resistance%20to%20epirubicin%20and%20mitoxantrone
抄録
内容記述タイプ Abstract
内容記述 Background: In order to understand the cross- resistance between epirubicin (EPI) and mitoxantrone (MIT), EPI- and MIT-resistant cells were established and their cross- resistance was evaluated. Materials and Methods: The degrees of growth inhibition of EPI-resistant HLE-EPI cells and MIT- resistant HLE-MIT cells by anticancer drugs were measured. The mRNA expressions of multidrug resistance protein 1 (MDR1)/ABCB1 and breast cancer resistance protein (BCRP)/ABCG2 were also measured by quantitative real-time RT-PCR. Moreover, intracellular accumulation of EPI was investigated. Results: HLE-EPI cells were resistant to EPI, MIT and docetaxel. HLE-MIT cells were resistant to EPI, MIT and SN-38. HLE-EPI cells overexpressed MDR1 and HLE-MIT cells overexpressed BCRP. The intracellular accumulation of EPI was decreased in HLE-EPI and HLE-MIT cells. Conclusion: The results suggest that both MDR1 and BCRP can up-regulate the efflux of EPI causing resistance to EPI in HLE-EPI and HLE-MIT cells.
注記
内容記述タイプ Other
注記 International Institute of Anticancer Research, NAOYA, KAMIYAMA ; SAORI, TAKAGI ; CHIAKI, YAMAMOTO ; TAKEAKI, KUDO ; TAKAHITO, NAKAGAWA ; MASATO, TAKAHASHI ; KAZUAKI, NAKANISHI ; HIROMASA, TAKAHASHI ; SATORU, TODO ; KEN, ISEKI, ANTICANCER RESEARCH, 26(2A), 2006, 885-888.
\nauthor
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資源タイプ text
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Cite as

神山, 直也, Takagi, S, Yamamoto, C, Kudo, T, Nakagawa, T, Takahashi, M, Nakanishi, K, Todo, S, Iseki, K, n.d., Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone: 885–888 p.

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