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Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone
https://asahikawa-med.repo.nii.ac.jp/records/714
https://asahikawa-med.repo.nii.ac.jp/records/714d38f8835-be31-468a-9a1f-780335b3f14f
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||||||||||
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公開日 | 2008-03-28 | |||||||||||||||||||||||||
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タイトル | Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone | |||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||
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言語 | eng | |||||||||||||||||||||||||
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資源タイプ | journal article | |||||||||||||||||||||||||
著者 |
神山, 直也
× 神山, 直也
× Takagi, S
× Yamamoto, C
× Kudo, T
× Nakagawa, T
× Takahashi, M
× Nakanishi, K
× Todo, S
× Iseki, K
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著者 ローマ字 | ||||||||||||||||||||||||||
Kamiyama, Naoya | ||||||||||||||||||||||||||
書誌情報 |
ANTICANCER RESEARCH 巻 26, 号 2A, p. 885-888, 発行日 2006-01-01 |
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収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
収録物識別子 | 0250-7005 | |||||||||||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||||||||||
内容記述 | http://www.ncbi.nlm.nih.gov/pubmed?term=Expression%20of%20ABC%20transporters%20in%20human%20hepatocyte%20carcinoma%20cells%20with%20cross-resistance%20to%20epirubicin%20and%20mitoxantrone | http://www.ncbi.nlm.nih.gov/pubmed?term=Expression%20of%20ABC%20transporters%20in%20human%20hepatocyte%20carcinoma%20cells%20with%20cross-resistance%20to%20epirubicin%20and%20mitoxantrone | |||||||||||||||||||||||||
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内容記述タイプ | Abstract | |||||||||||||||||||||||||
内容記述 | Background: In order to understand the cross- resistance between epirubicin (EPI) and mitoxantrone (MIT), EPI- and MIT-resistant cells were established and their cross- resistance was evaluated. Materials and Methods: The degrees of growth inhibition of EPI-resistant HLE-EPI cells and MIT- resistant HLE-MIT cells by anticancer drugs were measured. The mRNA expressions of multidrug resistance protein 1 (MDR1)/ABCB1 and breast cancer resistance protein (BCRP)/ABCG2 were also measured by quantitative real-time RT-PCR. Moreover, intracellular accumulation of EPI was investigated. Results: HLE-EPI cells were resistant to EPI, MIT and docetaxel. HLE-MIT cells were resistant to EPI, MIT and SN-38. HLE-EPI cells overexpressed MDR1 and HLE-MIT cells overexpressed BCRP. The intracellular accumulation of EPI was decreased in HLE-EPI and HLE-MIT cells. Conclusion: The results suggest that both MDR1 and BCRP can up-regulate the efflux of EPI causing resistance to EPI in HLE-EPI and HLE-MIT cells. | |||||||||||||||||||||||||
注記 | ||||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||||
注記 | International Institute of Anticancer Research, NAOYA, KAMIYAMA ; SAORI, TAKAGI ; CHIAKI, YAMAMOTO ; TAKEAKI, KUDO ; TAKAHITO, NAKAGAWA ; MASATO, TAKAHASHI ; KAZUAKI, NAKANISHI ; HIROMASA, TAKAHASHI ; SATORU, TODO ; KEN, ISEKI, ANTICANCER RESEARCH, 26(2A), 2006, 885-888. \nauthor |
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内容記述タイプ | Other | |||||||||||||||||||||||||
資源タイプ | text | |||||||||||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||||||||||
内容記述 | application/pdf | |||||||||||||||||||||||||
ID(XooNIps) | ||||||||||||||||||||||||||
16619483 | ||||||||||||||||||||||||||
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902 |
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Cite as
神山, 直也, Takagi, S, Yamamoto, C, Kudo, T, Nakagawa, T, Takahashi, M, Nakanishi, K, Todo, S, Iseki, K, n.d., Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone: 885–888 p.
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