| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2008-03-28 |
| タイトル |
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タイトル |
Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
神山, 直也
Takagi, S
Yamamoto, C
Kudo, T
Nakagawa, T
Takahashi, M
Nakanishi, K
Todo, S
Iseki, K
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| 著者 ローマ字 |
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Kamiyama, Naoya |
| 書誌情報 |
ANTICANCER RESEARCH
巻 26,
号 2A,
p. 885-888,
発行日 2006-01-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0250-7005 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed?term=Expression%20of%20ABC%20transporters%20in%20human%20hepatocyte%20carcinoma%20cells%20with%20cross-resistance%20to%20epirubicin%20and%20mitoxantrone | http://www.ncbi.nlm.nih.gov/pubmed?term=Expression%20of%20ABC%20transporters%20in%20human%20hepatocyte%20carcinoma%20cells%20with%20cross-resistance%20to%20epirubicin%20and%20mitoxantrone |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: In order to understand the cross- resistance between epirubicin (EPI) and mitoxantrone (MIT), EPI- and MIT-resistant cells were established and their cross- resistance was evaluated. Materials and Methods: The degrees of growth inhibition of EPI-resistant HLE-EPI cells and MIT- resistant HLE-MIT cells by anticancer drugs were measured. The mRNA expressions of multidrug resistance protein 1 (MDR1)/ABCB1 and breast cancer resistance protein (BCRP)/ABCG2 were also measured by quantitative real-time RT-PCR. Moreover, intracellular accumulation of EPI was investigated. Results: HLE-EPI cells were resistant to EPI, MIT and docetaxel. HLE-MIT cells were resistant to EPI, MIT and SN-38. HLE-EPI cells overexpressed MDR1 and HLE-MIT cells overexpressed BCRP. The intracellular accumulation of EPI was decreased in HLE-EPI and HLE-MIT cells. Conclusion: The results suggest that both MDR1 and BCRP can up-regulate the efflux of EPI causing resistance to EPI in HLE-EPI and HLE-MIT cells. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
International Institute of Anticancer Research, NAOYA, KAMIYAMA ; SAORI, TAKAGI ; CHIAKI, YAMAMOTO ; TAKEAKI, KUDO ; TAKAHITO, NAKAGAWA ; MASATO, TAKAHASHI ; KAZUAKI, NAKANISHI ; HIROMASA, TAKAHASHI ; SATORU, TODO ; KEN, ISEKI, ANTICANCER RESEARCH, 26(2A), 2006, 885-888.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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16619483 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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902 |
894.pdf (188.9 kB)
