{"created":"2023-06-19T11:20:39.161627+00:00","id":714,"links":{},"metadata":{"_buckets":{"deposit":"ac9453b5-ce82-4101-8645-794bf707aca9"},"_deposit":{"created_by":3,"id":"714","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"714"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000714","sets":["7","7:24"]},"author_link":["1979","1980","1981","1982","1983","1984","1985","1986","1987"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2A","bibliographicPageEnd":"888","bibliographicPageStart":"885","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"ANTICANCER RESEARCH"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.ncbi.nlm.nih.gov/pubmed?term=Expression%20of%20ABC%20transporters%20in%20human%20hepatocyte%20carcinoma%20cells%20with%20cross-resistance%20to%20epirubicin%20and%20mitoxantrone | http://www.ncbi.nlm.nih.gov/pubmed?term=Expression%20of%20ABC%20transporters%20in%20human%20hepatocyte%20carcinoma%20cells%20with%20cross-resistance%20to%20epirubicin%20and%20mitoxantrone","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: In order to understand the cross- resistance between epirubicin (EPI) and mitoxantrone (MIT), EPI- and MIT-resistant cells were established and their cross- resistance was evaluated. Materials and Methods: The degrees of growth inhibition of EPI-resistant HLE-EPI cells and MIT- resistant HLE-MIT cells by anticancer drugs were measured. The mRNA expressions of multidrug resistance protein 1 (MDR1)/ABCB1 and breast cancer resistance protein (BCRP)/ABCG2 were also measured by quantitative real-time RT-PCR. Moreover, intracellular accumulation of EPI was investigated. Results: HLE-EPI cells were resistant to EPI, MIT and docetaxel. HLE-MIT cells were resistant to EPI, MIT and SN-38. HLE-EPI cells overexpressed MDR1 and HLE-MIT cells overexpressed BCRP. The intracellular accumulation of EPI was decreased in HLE-EPI and HLE-MIT cells. Conclusion: The results suggest that both MDR1 and BCRP can up-regulate the efflux of EPI causing resistance to EPI in HLE-EPI and HLE-MIT cells.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"International Institute of Anticancer Research, NAOYA, KAMIYAMA ; SAORI, TAKAGI ; CHIAKI, YAMAMOTO ; TAKEAKI, KUDO ; TAKAHITO, NAKAGAWA ; MASATO, TAKAHASHI ; KAZUAKI, NAKANISHI ; HIROMASA, TAKAHASHI ; SATORU, TODO ; KEN, ISEKI, ANTICANCER RESEARCH, 26(2A), 2006, 885-888.\n\\nauthor","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0250-7005","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"16619483"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2567"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"902"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kamiyama, Naoya"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"神山, 直也"},{"creatorName":"カミヤマ, ナオヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takagi, S"}],"nameIdentifiers":[{"nameIdentifier":"1980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, C"}],"nameIdentifiers":[{"nameIdentifier":"1981","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kudo, T"}],"nameIdentifiers":[{"nameIdentifier":"1982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakagawa, T"}],"nameIdentifiers":[{"nameIdentifier":"1983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, M"}],"nameIdentifiers":[{"nameIdentifier":"1984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, K"}],"nameIdentifiers":[{"nameIdentifier":"1985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Todo, S"}],"nameIdentifiers":[{"nameIdentifier":"1986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iseki, K"}],"nameIdentifiers":[{"nameIdentifier":"1987","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"894.pdf","filesize":[{"value":"188.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"894.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/714/files/894.pdf"},"version_id":"869036dc-4269-4bf2-843b-8279f5c34d4b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-03-28"},"publish_date":"2008-03-28","publish_status":"0","recid":"714","relation_version_is_last":true,"title":["Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:29:52.135810+00:00"}