| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-10-29 |
| タイトル |
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タイトル |
Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
吉田, 成孝
Terayama, R
Bando, Y
Jiang, YP
Mitrovic, B
|
| 著者 ローマ字 |
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Yoshida, Shigetaka |
| 書誌情報 |
Neuroscience Letters
巻 382,
号 1-2,
p. 82-87,
発行日 2005-07-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0304-3940 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.neulet.2005.03.022 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/journal/03043940 | http://www.sciencedirect.com/science/journal/03043940 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
To determine the possible involvement of protease M/neurosin in demyelinating diseases of the CNS, we examined its expression in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), a recognized animal model of multiple sclerosis (MS). In situ hybridization, immunohistochemistry and quantitative real-time polymerase chain reaction (PCR) demonstrated that EAE caused an increase in the expression of protease M/neurosin mRNA and its protein product throughout the white and gray matter surrounding demyelinating lesions. Combined in situ hybridization and immunohistochemistry demonstrated that most of the cells expressing protease M/neurosin mRNA within control spinal cord showed immunoreactivity for CNPase or NG2, cell-specific markers for oligodendrocytes and their progenitors, respectively. In the spinal cord from mice with EAE, the expression of protease M/neurosin mRNA in CNPase-positive cells appeared to be increased while double-labeled cells positive for protease M/neurosin mRNA and NG2 were rarely found in areas associated with demyelinating lesions. Although a prominent accumulation of inflammatory cells including T-cells was observed in the vicinity of demyelinated lesions, these cells were not associated with protease M/neurosin mRNA expression. The levels of protease M/neurosin mRNA expression were unchanged in the spleen and even decreased in the thymus during the course of EAE. These observations suggest that the differential expression of protease M/neurosin in mature oligodendrocytes and their progenitors is involved in the pathogenesis of MS and EAE. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Elsevier, Terayama, Ryuji ; Bando, Yoshio ; Jiang, Ying-Ping ; Mitrovic, Branka ; Yoshida, Shigetaka, Neuroscience Letters, 382(1-2), 2005, 82-87.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15911126 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1302 |
767.pdf (261.4 kB)
