{"created":"2023-06-19T11:20:33.751700+00:00","id":610,"links":{},"metadata":{"_buckets":{"deposit":"d7a9ac1f-025d-4490-a52d-bc2c5b88a391"},"_deposit":{"created_by":3,"id":"610","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"610"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000610","sets":["7","7:24"]},"author_link":["1371","1372","1373","1374","1375"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"87","bibliographicPageStart":"82","bibliographicVolumeNumber":"382","bibliographic_titles":[{"bibliographic_title":"Neuroscience Letters"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/03043940 | http://www.sciencedirect.com/science/journal/03043940","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To determine the possible involvement of protease M/neurosin in demyelinating diseases of the CNS, we examined its expression in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), a recognized animal model of multiple sclerosis (MS). In situ hybridization, immunohistochemistry and quantitative real-time polymerase chain reaction (PCR) demonstrated that EAE caused an increase in the expression of protease M/neurosin mRNA and its protein product throughout the white and gray matter surrounding demyelinating lesions. Combined in situ hybridization and immunohistochemistry demonstrated that most of the cells expressing protease M/neurosin mRNA within control spinal cord showed immunoreactivity for CNPase or NG2, cell-specific markers for oligodendrocytes and their progenitors, respectively. In the spinal cord from mice with EAE, the expression of protease M/neurosin mRNA in CNPase-positive cells appeared to be increased while double-labeled cells positive for protease M/neurosin mRNA and NG2 were rarely found in areas associated with demyelinating lesions. Although a prominent accumulation of inflammatory cells including T-cells was observed in the vicinity of demyelinated lesions, these cells were not associated with protease M/neurosin mRNA expression. The levels of protease M/neurosin mRNA expression were unchanged in the spleen and even decreased in the thymus during the course of EAE. These observations suggest that the differential expression of protease M/neurosin in mature oligodendrocytes and their progenitors is involved in the pathogenesis of MS and EAE.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Elsevier, Terayama, Ryuji ; Bando, Yoshio ; Jiang, Ying-Ping ; Mitrovic, Branka ; Yoshida, Shigetaka, Neuroscience Letters, 382(1-2), 2005, 82-87.\n\\nauthor","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neulet.2005.03.022","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0304-3940","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"15911126"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"3347"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1302"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Yoshida, Shigetaka"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 成孝"},{"creatorName":"ヨシダ, シゲタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Terayama, R"}],"nameIdentifiers":[{"nameIdentifier":"1372","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bando, Y"}],"nameIdentifiers":[{"nameIdentifier":"1373","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jiang, YP"}],"nameIdentifiers":[{"nameIdentifier":"1374","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mitrovic, B"}],"nameIdentifiers":[{"nameIdentifier":"1375","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"767.pdf","filesize":[{"value":"261.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"767.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/610/files/767.pdf"},"version_id":"0bea0f70-baae-4d28-9fe9-9a26f24443a4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-10-29"},"publish_date":"2007-10-29","publish_status":"0","recid":"610","relation_version_is_last":true,"title":["Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:33:21.849434+00:00"}