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A nationwide comparison between Sepsis-2 and Sepsis-3 definition in Japan

https://asahikawa-med.repo.nii.ac.jp/records/6079
https://asahikawa-med.repo.nii.ac.jp/records/6079
59018378-41a1-498d-8494-d6f9945515f1
名前 / ファイル ライセンス アクション
7256.pdf 7256.pdf (131.3 kB)
Item type 学位論文 / Thesis or Dissertation_02(1)
公開日 2019-08-01
タイトル
タイトル A nationwide comparison between Sepsis-2 and Sepsis-3 definition in Japan
言語 en
言語
言語 jpn
キーワード
主題Scheme Other
主題 Sepsis-3
キーワード
主題Scheme Other
主題 mortality
キーワード
主題Scheme Other
主題 organ failure
キーワード
主題Scheme Other
主題 septic shock
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_46ec
資源タイプ thesis
著者 高氏, 修平

× 高氏, 修平

ja 高氏, 修平

ja-Kana タカウジ, シュウヘイ

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著者 ローマ字
Takauji, Shuhei
書誌情報 Journal of intensive care medicine

発行日 2019-01-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0885-0666
DOI
識別子タイプ DOI
関連識別子 10.1177/0885066618823151
識別番号 その他
内容記述タイプ Other
内容記述 PMID:30636495
学位授与番号
学位授与番号 10107B481
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 旭川医科大学
抄録
内容記述タイプ Abstract
内容記述 BACKGROUND::
\nCurrently, it remains controversial whether the Sepsis-3 definition provides the most appropriate criteria for clinical use. The purpose of this study was to compare between the Sepsis-2 and Sepsis-3 definitions using Japan's nationwide registry.
METHODS::
\nData were obtained from a multicenter registry conducted at 42 intensive care units (ICUs) throughout Japan, in which patients received treatment for severe sepsis or septic shock between January 2011 and December 2013.
RESULTS::
\nA total of 2797 patients diagnosed using the Sepsis-2 criteria were included in the present study. These patients were categorized into "Severe sepsis" (n = 1154) and "Sepsis-2 shock" (n = 1643) groups. Among the "Sepsis-2 shock" group, patients who did not meet the Sepsis-3 criteria for septic shock were categorized into the "Sepsis-2 shock-only" (n = 448, 27.3%) group, while patients who met the Sepsis-3 criteria for septic shock were categorized into "Sepsis-3 shock (n = 1195, 72.7%)" group. The ICU mortality in the "Sepsis-3 shock" group, "Sepsis-2 shock-only" group, and "Severe sepsis" group was 28.5%, 10.9%, and 14.1%, respectively. We observed no significant difference between the "Severe sepsis" and "Sepsis-2 shock-only" groups in terms of in-hospital survival ( P = .098), while the "Sepsis-3 shock" group had the highest in-hospital mortality rate ( P < .001). In a multivariate logistic regression analysis, liver insufficiency and immunocompromised status were independent prognostic factors in the "Sepsis-2 shock-only" group. In contrast, chronic heart disease and chronic hemodialysis were independent prognostic factors in the "Sepsis-3 shock" group.
CONCLUSIONS::
\nThe ICU mortality of the "Sepsis-2 shock-only" group was significantly low. Besides septic shock diagnosed by the Sepsis-3 definition selects patients with more severe cases of sepsis among the "Sepsis-2 shock" group.
資源タイプ
内容記述タイプ Other
内容記述 application/pdf
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内容記述 application/pdf
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