| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2018-05-31 |
| タイトル |
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タイトル |
Applicability of Combined Use of Extracorporeal Support and Temperature-Controlled Machine Perfusion Preservation for Liver Procurement of Donors After Cardiac Death in Pigs. |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
萩原, 正弘
松野, 直徒
Ling, tong Meng
古郡, 茉利子
渡邉, 賢二
庄中, 達也
今井, 浩二
小原, 弘道
西川, 祐司
古川, 博之
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| 著者 ローマ字 |
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Hagiwara, Masahiro |
| 著者 ローマ字 |
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Matsuno, Naoto |
| 著者 ローマ字 |
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| 著者 ローマ字 |
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Furukori, Mariko |
| 著者 ローマ字 |
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Watanabe, Kenji |
| 著者 ローマ字 |
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Shonaka, Tatsuya |
| 著者 ローマ字 |
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Imai, Koji |
| 著者 ローマ字 |
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Obara, Hiromichi |
| 著者 ローマ字 |
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Nishikawa, Yuji |
| 著者 ローマ字 |
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Furukawa, Hiroyuki |
| 書誌情報 |
Transplantation proceedings
巻 48,
号 4,
p. 1234-1238,
発行日 2016-05-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0041-1345 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.transproceed.2015.12.087 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
BACKGROUND:
\nThe use of grafts from donors after cardiac death (DCD) would greatly contribute to the expansion of the donor organ pool. The objective of this study is to determine the benefits of extracorporeal membrane oxygenation (ECMO) and subnormothermic machine perfusion (MP) with rewarming in a large animal model of DCD liver.
METHODS:
\nAfter cardiac arrest, the abdominal aorta and the inferior vena cava were cannulated and connected to an ECMO circuit. Porcine livers were perfused in situ with ECMO at 22°C for 60 minutes after 60 minutes of cardiac death. Then the livers were perfused for 4 hours by MP as a graft viability test. In group 1, non-in situ ECMO and grafts were preserved hypothermic MP. In group 2, non-in situ ECMO and grafts were preserved subnormothermic rewarming MP. In group 3, we used ECMO and subnormothermic rewarming MP. To assess potential methods and effect, effluent enzymes were measured. Portal vein and hepatic artery pressure during MP were evaluated.
RESULTS:
\nEffluent enzyme of AST, alanine aminotransferase and LDH as viability markers were significantly low (aspartate aminotransferase, 2899, 2292, and 972 IU/L; alanine aminotransferase, 134, 140, and 72 IU/L; and lactate dehydrogenase, 4354, 4455, and 1855 IU/L in each group, respectively). Portal vein and hepatic artery pressure during preservation came down smoothly in group 3 compared with group 1.
CONCLUSIONS:
\nThe combined use of in situ subnormothermic ECMO and machine preservation with rewarming is more essential for the recovery and resuscitating function of DCD liver grafts. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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27320594 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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506 |
7001.pdf (5.4 MB)
