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Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor.
https://asahikawa-med.repo.nii.ac.jp/records/5888
https://asahikawa-med.repo.nii.ac.jp/records/588885351f71-c544-4ab9-939b-b4dbf2f03356
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2017-04-13 | |||||
タイトル | ||||||
タイトル | Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Corticotropin-releasing factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytokine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mast cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Repeated water avoidance stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Visceral allodynia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
野津, 司
× 野津, 司× 宮岸, 沙織× 野津, 麟太郎× 高草木, 薫× 奥村, 利勝 |
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著者 ローマ字 | ||||||
値 | Nozu, Tsukasa | |||||
著者 ローマ字 | ||||||
値 | Miyagishi, Saori | |||||
著者 ローマ字 | ||||||
値 | Nozu, Rintaro | |||||
著者 ローマ字 | ||||||
値 | Takakusaki, Kaoru | |||||
著者 ローマ字 | ||||||
値 | Okumura, Toshikatsu | |||||
書誌情報 |
Journal of gastroenterology and hepatology. p. 1-25, 発行日 2017-03-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0815-9319 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/jgh.13787. | |||||
リンクURL | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://onlinelibrary.wiley.com/doi/10.1111/jgh.13787/full | http://onlinelibrary.wiley.com/doi/10.1111/jgh.13787/full | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:28299830 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND AND AIM: \nRepeated water avoidance stress (WAS) induces visceral hypersensitivity. Additionally, it is also known to activate corticotropin-releasing factor (CRF), mast cells and pro-inflammatory cytokines systems, but their precise roles on visceral sensation have not been determined definitely. The aim of the study was to explore this issue. METHODS: \nAbdominal muscle contractions induced by colonic balloon distention, i.e. visceromotor response (VMR) was detected electrophysiologically in conscious rats. WAS or sham stress as control for 1 hr daily was loaded and the threshold of VMR was determined before and at 24 hr after the stress. RESULTS: \nRepeated WAS for 3 consecutive days reduced the threshold of VMR, but sham stress did not induce any change. Astressin, a CRF receptor antagonist (50 µg/kg) intraperitoneally (ip) at 10 min prior to each WAS session prevented the visceral allodynia, but the antagonist (200 µg/kg) ip at 30 min and 15 hr before measurement of the threshold after completing 3-day stress session did not modify the response. Ketotifen, a mast cell stabilizer (3 mg/kg), anakinra, an interleukin (IL)-1 receptor antagonist (20 mg/kg) or IL-6 antibody (16.6 µg/kg) ip for 2 times before the measurement abolished the response. CONCLUSIONS: \nRepeated WAS for 3 consecutive days induced visceral allodynia which was mediated through mast cells, IL-1 and IL-6 pathways. Inhibition of peripheral CRF signaling prevented but did not reverse this response, suggesting that peripheral CRF may be an essential trigger but may not contribute to the maintenance of repeated WAS-induced visceral allodynia. |
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資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
値 | 28299830 | |||||
閲覧数(XooNIps) | ||||||
値 | 637 | |||||
ダウンロード数(XooNIps) | ||||||
値 | 719 |