{"created":"2023-06-19T11:25:04.515934+00:00","id":5888,"links":{},"metadata":{"_buckets":{"deposit":"aa7b6ee0-623c-4218-b138-a26b574bd497"},"_deposit":{"created_by":1,"id":"5888","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5888"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005888","sets":["7","7:24"]},"author_link":["18417","18418","18416","18415","18419"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"25","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"Journal of gastroenterology and hepatology."}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://onlinelibrary.wiley.com/doi/10.1111/jgh.13787/full | http://onlinelibrary.wiley.com/doi/10.1111/jgh.13787/full","subitem_description_type":"Other"}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：28299830","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND AND AIM:\n\\nRepeated water avoidance stress (WAS) induces visceral hypersensitivity. Additionally, it is also known to activate corticotropin-releasing factor (CRF), mast cells and pro-inflammatory cytokines systems, but their precise roles on visceral sensation have not been determined definitely. The aim of the study was to explore this issue.\nMETHODS:\n\\nAbdominal muscle contractions induced by colonic balloon distention, i.e. visceromotor response (VMR) was detected electrophysiologically in conscious rats. WAS or sham stress as control for 1 hr daily was loaded and the threshold of VMR was determined before and at 24 hr after the stress.\nRESULTS:\n\\nRepeated WAS for 3 consecutive days reduced the threshold of VMR, but sham stress did not induce any change. Astressin, a CRF receptor antagonist (50 µg/kg) intraperitoneally (ip) at 10 min prior to each WAS session prevented the visceral allodynia, but the antagonist (200 µg/kg) ip at 30 min and 15 hr before measurement of the threshold after completing 3-day stress session did not modify the response. Ketotifen, a mast cell stabilizer (3 mg/kg), anakinra, an interleukin (IL)-1 receptor antagonist (20 mg/kg) or IL-6 antibody (16.6 µg/kg) ip for 2 times before the measurement abolished the response.\nCONCLUSIONS:\n\\nRepeated WAS for 3 consecutive days induced visceral allodynia which was mediated through mast cells, IL-1 and IL-6 pathways. Inhibition of peripheral CRF signaling prevented but did not reverse this response, suggesting that peripheral CRF may be an essential trigger but may not contribute to the maintenance of repeated WAS-induced visceral allodynia.","subitem_description_type":"Abstract"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/jgh.13787.","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0815-9319","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"28299830"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"637"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"719"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Nozu, Tsukasa"},{"subitem_text_value":"Miyagishi, Saori"},{"subitem_text_value":"Nozu, Rintaro"},{"subitem_text_value":"Takakusaki, Kaoru"},{"subitem_text_value":"Okumura, Toshikatsu"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野津, 司"},{"creatorName":"ノヅ, ツカサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮岸, 沙織"},{"creatorName":"ミヤギシ, サオリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野津, 麟太郎"},{"creatorName":"ノズ, リンタロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高草木, 薫"},{"creatorName":"タカクサキ, カオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥村, 利勝"},{"creatorName":"オクムラ, トシカツ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18419","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6700.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6700.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5888/files/6700.pdf"},"version_id":"90e91c7b-2063-449e-80c8-7febfd92bf5f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Corticotropin-releasing factor","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"Mast cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Repeated water avoidance stress","subitem_subject_scheme":"Other"},{"subitem_subject":"Visceral allodynia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-04-13"},"publish_date":"2017-04-13","publish_status":"0","recid":"5888","relation_version_is_last":true,"title":["Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:09:08.417142+00:00"}