WEKO3
アイテム
{"_buckets": {"deposit": "a077accb-2cfd-4bee-b524-08f92eec88e4"}, "_deposit": {"created_by": 1, "id": "5872", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "5872"}, "status": "published"}, "_oai": {"id": "oai:asahikawa-med.repo.nii.ac.jp:00005872", "sets": ["7", "24"]}, "author_link": ["18376", "18375", "18372", "18373", "18374", "18371"], "item_5_biblio_info_21": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-03-01", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "574", "bibliographicPageStart": "567", "bibliographicVolumeNumber": "10", "bibliographic_titles": [{"bibliographic_title": "Journal of pain research"}]}]}, "item_5_description_28": {"attribute_name": "識別番号 その他", "attribute_value_mlt": [{"subitem_description": "PMID:28331359", "subitem_description_type": "Other"}]}, "item_5_description_33": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "PURPOSE:\n\\nPregnancy-induced analgesia develops during late pregnancy, but it is unclear whether this analgesia is effective against neuropathic pain. The detailed molecular mechanisms underlying pregnancy-induced analgesia have not been investigated. We examined the antinociceptive effect of pregnancy-induced analgesia in a neuropathic pain model and the expression of tumor necrosis factor (TNF)-α, glial fibrillary acidic protein (GFAP), Iba-1, and c-Fos in the spinal dorsal horn just before parturition.\nMATERIALS AND METHODS:\n\\nFemale Sprague Dawley rats (200-250 g) were randomly assigned to one of four groups (pregnant + chronic constriction injury [CCI]; pregnant + sham injury; not pregnant + CCI; and not pregnant + sham injury). Separate groups were used for the behavioral and tissue analyses. CCI of the left sciatic nerve was surgically induced 3 days after confirming pregnancy in the pregnancy group or on day 3 in the not pregnant group. The spinal cord was extracted 18 days after CCI. TNF-α, GFAP, Iba-1, and c-Fos expression levels in the spinal dorsal horn were measured by Western blot analysis. Mechanical threshold was tested using von Frey filaments.\nRESULTS:\n\\nThe lowered mechanical threshold induced by CCI was significantly attenuated within 1 day before parturition and decreased after delivery. TNF-α expression in CCI rats was decreased within 1 day before parturition. Further, GFAP, Iba-1, and c-Fos expression in the spinal dorsal horn was reduced in the pregnant rats. Serum TNF-α in all groups was below measurable limits.\nCONCLUSION:\n\\nOur findings indicate that pregnancy-induced analgesia suppresses neuropathic pain through reducing spinal levels of TNF-α, GFAP, Iba-1, and c-Fos in a rat model of CCI.", "subitem_description_type": "Abstract"}]}, "item_5_description_36": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License", "subitem_description_type": "Other"}]}, "item_5_description_37": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "text", "subitem_description_type": "Other"}]}, "item_5_description_41": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_5_relation_24": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.2147/JPR.S121810", "subitem_relation_type_select": "DOI"}}]}, "item_5_source_id_22": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1178-7090", "subitem_source_identifier_type": "ISSN"}]}, "item_5_text_44": {"attribute_name": "ID(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "28331359"}]}, "item_5_text_51": {"attribute_name": "最終更新日(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "Feb 27, 2018 16:54:41"}]}, "item_5_text_53": {"attribute_name": "登録者(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "Library"}]}, "item_5_text_54": {"attribute_name": "閲覧数(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "388"}]}, "item_5_text_55": {"attribute_name": "ダウンロード数(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "530"}]}, "item_5_text_56": {"attribute_name": "XooNIps_ITEM_KEY", "attribute_value_mlt": [{"subitem_text_value": "6964"}]}, "item_5_text_7": {"attribute_name": "著者 ローマ字", "attribute_value_mlt": [{"subitem_text_value": "Onodera, Yoshiko"}, {"subitem_text_value": "Kanao-Kanda, Megumi"}, {"subitem_text_value": "Kanda, Hirotsugu"}, {"subitem_text_value": "Sasakawa, Tomoki"}, {"subitem_text_value": "Iwasaki, Hiroshi"}, {"subitem_text_value": "Kunisawa, Takayuki"}]}, "item_5_version_type_38": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小野寺, 美子"}, {"creatorName": "オノデラ, ヨシコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "18371", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "神田, 恵"}, {"creatorName": "カンダ, メグミ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "18372", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "神田, 浩嗣"}, {"creatorName": "カンダ, ヒロツグ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "18373", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "笹川, 智貴"}, {"creatorName": "ササカワ, トモキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "18374", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岩崎, 寛"}, {"creatorName": "イワサキ, ヒロシ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "18375", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "国沢, 卓之"}, {"creatorName": "クニサワ, タカユキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "18376", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-07-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "6964.pdf", "filesize": [{"value": "856.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 856100.0, "url": {"label": "6964.pdf", "url": "https://asahikawa-med.repo.nii.ac.jp/record/5872/files/6964.pdf"}, "version_id": "87b55dd6-db57-4ebf-a5ba-5403706403dc"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "TNF-α", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glial cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neuropathic pain", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pregnancy-induced analgesia", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α."}]}, "item_type_id": "5", "owner": "1", "path": ["6", "7", "24"], "permalink_uri": "https://asahikawa-med.repo.nii.ac.jp/records/5872", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-02-27"}, "publish_date": "2018-02-27", "publish_status": "0", "recid": "5872", "relation": {}, "relation_version_is_last": true, "title": ["Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α."], "weko_shared_id": -1}
Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α.
https://asahikawa-med.repo.nii.ac.jp/records/5872
https://asahikawa-med.repo.nii.ac.jp/records/5872d83ce2b8-c7f3-4452-9d80-acae0df34358
名前 / ファイル | ライセンス | アクション |
---|---|---|
6964.pdf (856.1 kB)
|
|
Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-02-27 | |||||
タイトル | ||||||
タイトル | Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | TNF-α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | glial cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | neuropathic pain | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | pregnancy-induced analgesia | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
小野寺, 美子
× 小野寺, 美子× 神田, 恵× 神田, 浩嗣× 笹川, 智貴× 岩崎, 寛× 国沢, 卓之 |
|||||
著者 ローマ字 | ||||||
Onodera, Yoshiko | ||||||
著者 ローマ字 | ||||||
Kanao-Kanda, Megumi | ||||||
著者 ローマ字 | ||||||
Kanda, Hirotsugu | ||||||
著者 ローマ字 | ||||||
Sasakawa, Tomoki | ||||||
著者 ローマ字 | ||||||
Iwasaki, Hiroshi | ||||||
著者 ローマ字 | ||||||
Kunisawa, Takayuki | ||||||
書誌情報 |
Journal of pain research 巻 10, p. 567-574, 発行日 2017-03-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1178-7090 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2147/JPR.S121810 | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:28331359 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: \nPregnancy-induced analgesia develops during late pregnancy, but it is unclear whether this analgesia is effective against neuropathic pain. The detailed molecular mechanisms underlying pregnancy-induced analgesia have not been investigated. We examined the antinociceptive effect of pregnancy-induced analgesia in a neuropathic pain model and the expression of tumor necrosis factor (TNF)-α, glial fibrillary acidic protein (GFAP), Iba-1, and c-Fos in the spinal dorsal horn just before parturition. MATERIALS AND METHODS: \nFemale Sprague Dawley rats (200-250 g) were randomly assigned to one of four groups (pregnant + chronic constriction injury [CCI]; pregnant + sham injury; not pregnant + CCI; and not pregnant + sham injury). Separate groups were used for the behavioral and tissue analyses. CCI of the left sciatic nerve was surgically induced 3 days after confirming pregnancy in the pregnancy group or on day 3 in the not pregnant group. The spinal cord was extracted 18 days after CCI. TNF-α, GFAP, Iba-1, and c-Fos expression levels in the spinal dorsal horn were measured by Western blot analysis. Mechanical threshold was tested using von Frey filaments. RESULTS: \nThe lowered mechanical threshold induced by CCI was significantly attenuated within 1 day before parturition and decreased after delivery. TNF-α expression in CCI rats was decreased within 1 day before parturition. Further, GFAP, Iba-1, and c-Fos expression in the spinal dorsal horn was reduced in the pregnant rats. Serum TNF-α in all groups was below measurable limits. CONCLUSION: \nOur findings indicate that pregnancy-induced analgesia suppresses neuropathic pain through reducing spinal levels of TNF-α, GFAP, Iba-1, and c-Fos in a rat model of CCI. |
|||||
注記 | ||||||
内容記述タイプ | Other | |||||
注記 | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
資源タイプ | text | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
28331359 | ||||||
閲覧数(XooNIps) | ||||||
388 | ||||||
ダウンロード数(XooNIps) | ||||||
530 |