{"created":"2023-06-19T11:25:03.674788+00:00","id":5872,"links":{},"metadata":{"_buckets":{"deposit":"a077accb-2cfd-4bee-b524-08f92eec88e4"},"_deposit":{"created_by":1,"id":"5872","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5872"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005872","sets":["7","7:24"]},"author_link":["18376","18375","18372","18373","18374","18371"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"574","bibliographicPageStart":"567","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Journal of pain research"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：28331359","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE:\n\\nPregnancy-induced analgesia develops during late pregnancy, but it is unclear whether this analgesia is effective against neuropathic pain. The detailed molecular mechanisms underlying pregnancy-induced analgesia have not been investigated. We examined the antinociceptive effect of pregnancy-induced analgesia in a neuropathic pain model and the expression of tumor necrosis factor (TNF)-α, glial fibrillary acidic protein (GFAP), Iba-1, and c-Fos in the spinal dorsal horn just before parturition.\nMATERIALS AND METHODS:\n\\nFemale Sprague Dawley rats (200-250 g) were randomly assigned to one of four groups (pregnant + chronic constriction injury [CCI]; pregnant + sham injury; not pregnant + CCI; and not pregnant + sham injury). Separate groups were used for the behavioral and tissue analyses. CCI of the left sciatic nerve was surgically induced 3 days after confirming pregnancy in the pregnancy group or on day 3 in the not pregnant group. The spinal cord was extracted 18 days after CCI. TNF-α, GFAP, Iba-1, and c-Fos expression levels in the spinal dorsal horn were measured by Western blot analysis. Mechanical threshold was tested using von Frey filaments.\nRESULTS:\n\\nThe lowered mechanical threshold induced by CCI was significantly attenuated within 1 day before parturition and decreased after delivery. TNF-α expression in CCI rats was decreased within 1 day before parturition. Further, GFAP, Iba-1, and c-Fos expression in the spinal dorsal horn was reduced in the pregnant rats. Serum TNF-α in all groups was below measurable limits.\nCONCLUSION:\n\\nOur findings indicate that pregnancy-induced analgesia suppresses neuropathic pain through reducing spinal levels of TNF-α, GFAP, Iba-1, and c-Fos in a rat model of CCI.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2147/JPR.S121810","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1178-7090","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"28331359"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"388"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"530"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Onodera, Yoshiko"},{"subitem_text_value":"Kanao-Kanda, Megumi"},{"subitem_text_value":"Kanda, Hirotsugu"},{"subitem_text_value":"Sasakawa, Tomoki"},{"subitem_text_value":"Iwasaki, Hiroshi"},{"subitem_text_value":"Kunisawa, Takayuki"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小野寺, 美子"},{"creatorName":"オノデラ, ヨシコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神田, 恵"},{"creatorName":"カンダ, メグミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18372","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神田, 浩嗣"},{"creatorName":"カンダ, ヒロツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18373","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笹川, 智貴"},{"creatorName":"ササカワ, トモキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18374","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩崎, 寛"},{"creatorName":"イワサキ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18375","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"国沢, 卓之"},{"creatorName":"クニサワ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18376","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6964.pdf","filesize":[{"value":"856.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6964.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5872/files/6964.pdf"},"version_id":"87b55dd6-db57-4ebf-a5ba-5403706403dc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TNF-α","subitem_subject_scheme":"Other"},{"subitem_subject":"glial cell","subitem_subject_scheme":"Other"},{"subitem_subject":"neuropathic pain","subitem_subject_scheme":"Other"},{"subitem_subject":"pregnancy-induced analgesia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-27"},"publish_date":"2018-02-27","publish_status":"0","recid":"5872","relation_version_is_last":true,"title":["Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:09:37.965313+00:00"}