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11-Ketotestosterone Is a Major Androgen Produced in Human Gonads
https://asahikawa-med.repo.nii.ac.jp/records/5737
https://asahikawa-med.repo.nii.ac.jp/records/57373e756e29-ba89-4a0c-a78d-aa7077b90e8e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6805.pdf (691.3 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2017-09-27 | |||||
| タイトル | ||||||
| タイトル | 11-Ketotestosterone Is a Major Androgen Produced in Human Gonads | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
今道, 力敬
× 今道, 力敬× 結城, 幸一× 折坂, 誠× 北野, 健× 向井, 邦晃× 牛首, 文隆× 谷口, 隆信× 梅澤, 明弘× 宮本, 薫× 矢澤, 隆志 |
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| 著者 ローマ字 | ||||||
| 値 | Imamichi, Yoshitaka | |||||
| 著者 ローマ字 | ||||||
| 値 | Yuki, Koh-ichi | |||||
| 著者 ローマ字 | ||||||
| 値 | Orisaka, Makoto | |||||
| 著者 ローマ字 | ||||||
| 値 | Kitano, Takeshi | |||||
| 著者 ローマ字 | ||||||
| 値 | Mukai, Kuniaki | |||||
| 著者 ローマ字 | ||||||
| 値 | Ushikubi, Fumitaka | |||||
| 著者 ローマ字 | ||||||
| 値 | Taniguchi, Takanobu | |||||
| 著者 ローマ字 | ||||||
| 値 | Umezawa, Akihiro | |||||
| 著者 ローマ字 | ||||||
| 値 | Miyamoto, Kaoru | |||||
| 著者 ローマ字 | ||||||
| 値 | Yazawa, Takashi | |||||
| 書誌情報 |
The Journal of Clinical Endocrinology and Metabolism 巻 101, 号 10, p. 3582-3591, 発行日 2016-07-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0021-972X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1210/jc.2016-2311 | |||||
| リンクURL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2016-2311 | https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2016-2311 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID：27428878 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | CONTEXT: \n11-ketotestosterone (11-KT) is a novel class of active androgen. However, the detail of its synthesis remains unknown for humans. OBJECTIVE: \nThe objective of this study was to clarify the production and properties of 11-KT in human. Design, Participants, and Methods: Expression of cytochrome P450 and 11β-hydroxysteroid dehydrogenase types 1 and 2 (key enzymes involved in the synthesis of 11-KT) were investigated in human gonads. The production of 11-KT was investigated in Leydig cells. Plasma concentrations of testosterone and 11-KT were measured in 10 women and 10 men of reproductive age. Investigation of its properties was performed using breast cancer-derived MCF-7 cells. RESULTS: \nCytochrome P450 and 11β-hydroxysteroid dehydrogenase types 1 and 2 were detected in Leydig cells and theca cells. Leydig cells produced 11-KT, and relatively high levels of plasma 11-KT were measured in both men and women. There was no sexual dimorphism in the plasma levels of 11-KT, even though testosterone levels were more than 20 times higher in men than in women. It is noteworthy that the levels of testosterone and 11-KT were similar in women. In a luciferase reporter system, 11-KT activated human androgen receptor-mediated transactivation. Conversely, 11-KT did not activate estrogen receptor-mediated transactivation in aromatase-expressed MCF-7 cells, whereas testosterone did following conversion to estrogen. 11-KT did not affect the estrogen/estrogen receptor -mediated cell proliferation of MCF-7 cells. Furthermore, it significantly inhibited cell proliferation when androgen receptor was transfected into MCF-7 cells. CONCLUSIONS: \nThe current study indicates that 11-KT is produced in the gonads and represents a major androgen in human. It can potentially serve as a nonaromatizable androgen. |
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| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 27428878 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 1461 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 1124 | |||||
