{"created":"2023-06-19T11:24:56.781964+00:00","id":5737,"links":{},"metadata":{"_buckets":{"deposit":"6103e431-87f9-4042-ba08-dd6edbe98d9e"},"_deposit":{"created_by":1,"id":"5737","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5737"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005737","sets":["7","7:24"]},"author_link":["18077","18075","18071","18072","18074","18076","18073","18078","18069","18070"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"3591","bibliographicPageStart":"3582","bibliographicVolumeNumber":"101","bibliographic_titles":[{"bibliographic_title":"The Journal of Clinical Endocrinology and Metabolism"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2016-2311 | https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2016-2311","subitem_description_type":"Other"}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：27428878","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CONTEXT:\n\\n11-ketotestosterone (11-KT) is a novel class of active androgen. However, the detail of its synthesis remains unknown for humans.\nOBJECTIVE:\n\\nThe objective of this study was to clarify the production and properties of 11-KT in human. Design, Participants, and Methods: Expression of cytochrome P450 and 11β-hydroxysteroid dehydrogenase types 1 and 2 (key enzymes involved in the synthesis of 11-KT) were investigated in human gonads. The production of 11-KT was investigated in Leydig cells. Plasma concentrations of testosterone and 11-KT were measured in 10 women and 10 men of reproductive age. Investigation of its properties was performed using breast cancer-derived MCF-7 cells.\nRESULTS:\n\\nCytochrome P450 and 11β-hydroxysteroid dehydrogenase types 1 and 2 were detected in Leydig cells and theca cells. Leydig cells produced 11-KT, and relatively high levels of plasma 11-KT were measured in both men and women. There was no sexual dimorphism in the plasma levels of 11-KT, even though testosterone levels were more than 20 times higher in men than in women. It is noteworthy that the levels of testosterone and 11-KT were similar in women. In a luciferase reporter system, 11-KT activated human androgen receptor-mediated transactivation. Conversely, 11-KT did not activate estrogen receptor-mediated transactivation in aromatase-expressed MCF-7 cells, whereas testosterone did following conversion to estrogen. 11-KT did not affect the estrogen/estrogen receptor -mediated cell proliferation of MCF-7 cells. Furthermore, it significantly inhibited cell proliferation when androgen receptor was transfected into MCF-7 cells.\nCONCLUSIONS:\n\\nThe current study indicates that 11-KT is produced in the gonads and represents a major androgen in human. It can potentially serve as a nonaromatizable androgen.","subitem_description_type":"Abstract"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1210/jc.2016-2311","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-972X","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"27428878"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1461"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1124"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Imamichi, Yoshitaka"},{"subitem_text_value":"Yuki, Koh-ichi"},{"subitem_text_value":"Orisaka, Makoto"},{"subitem_text_value":"Kitano, Takeshi"},{"subitem_text_value":"Mukai, Kuniaki"},{"subitem_text_value":"Ushikubi, Fumitaka"},{"subitem_text_value":"Taniguchi, Takanobu"},{"subitem_text_value":"Umezawa, Akihiro"},{"subitem_text_value":"Miyamoto, Kaoru"},{"subitem_text_value":"Yazawa, Takashi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今道, 力敬"},{"creatorName":"イマミチ, ヨシタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"結城, 幸一"},{"creatorName":"ユウキ, コウイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"折坂, 誠"},{"creatorName":"オリサカ, マコト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北野, 健"},{"creatorName":"キタノ, タケシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"向井, 邦晃"},{"creatorName":"ムカイ, クニアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"牛首, 文隆"},{"creatorName":"ウシクビ, フミタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷口, 隆信"},{"creatorName":"タニグチ, タカノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"梅澤, 明弘"},{"creatorName":"ウメザワ, アキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18076","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮本, 薫"},{"creatorName":"ミヤモト, カオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"矢澤, 隆志"},{"creatorName":"ヤザワ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18078","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6805.pdf","filesize":[{"value":"691.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6805.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5737/files/6805.pdf"},"version_id":"6804026f-511a-4694-aaf1-3117683290f2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"11-Ketotestosterone Is a Major Androgen Produced in Human Gonads","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"11-Ketotestosterone Is a Major Androgen Produced in Human Gonads"}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-27"},"publish_date":"2017-09-27","publish_status":"0","recid":"5737","relation_version_is_last":true,"title":["11-Ketotestosterone Is a Major Androgen Produced in Human Gonads"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:13:53.087499+00:00"}