| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2017-09-26 |
| タイトル |
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タイトル |
Malnutrition, renal dysfunction and left ventricular hypertrophy synergistically increase the long-term incidence of cardiovascular events. |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
丸山, 啓介
中川, 直樹
齊藤, 江里香
松木, 孝樹
竹原, 有史
赤坂, 和美
佐藤, 伸之
長谷部, 直幸
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| 著者 ローマ字 |
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Maruyama, Keisuke |
| 著者 ローマ字 |
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Nakagawa, Naoki |
| 著者 ローマ字 |
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Saito, Erika |
| 著者 ローマ字 |
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Matsuki, Motoki |
| 著者 ローマ字 |
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Takehara, Naofumi |
| 著者 ローマ字 |
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Akasaka, Kazumi |
| 著者 ローマ字 |
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Sato, Nobuyuki |
| 著者 ローマ字 |
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Hasebe, Naoyuki |
| 書誌情報 |
Hypertension Research
号 39,
p. 633-639,
発行日 2016-09-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0916-9636 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/hr.2016.47 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID：27169395 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Although malnutrition indicates an unfavorable prognosis in some clinical settings, the synergistic impact of nutritional state, renal dysfunction and left ventricular hypertrophy (LVH) on cardiovascular events is unknown. Among 338 patients aged 40-80 years who underwent echocardiographic evaluation between 2003 and 2005, 161 patients who were followed for >7 years were recruited. Malnutrition was defined as a geriatric nutritional risk index (GNRI) of ⩽96. The mean patient age was 63.5±9.2 years; the mean estimated glomerular filtration rate (eGFR) was 72.9±18.7 ml min(-1) per 1.73 m(2); the mean LV mass index was 114±33 g m(-)(2); and the mean GNRI was 100.4±6.0. Among the patients, 25% (n=40) had an eGFR of <60 ml min(-1) per 1.73 m(2), 29% (n=46) exhibited chronic kidney disease (CKD) and 37% (n=59) had LVH. During the follow-up period (median: 96 months), cardiovascular events were observed in 15 patients (9%). Kaplan-Meier curves showed a significantly higher incidence of cardiovascular events in patients with an eGFR of <60 ml min(-1) per 1.73 m(2) (log-rank P=0.007), a GNRI of ⩽96 (P=0.003) or LVH (P=0.010). In a Cox regression analysis, eGFR, LVH and GNRI were independent determinants of cardiovascular event incidence after adjusting for age, gender and the presence of hypertension and diabetes. Furthermore, the combination of LVH and lower GNRI was significantly associated with a higher rate of cardiovascular events not only in all patients but also in patients with CKD. In conclusion, malnutrition, low eGFR and LVH were independent determinants of cardiovascular event incidence; they synergistically increased rates of these events in the long term. The evaluation and management of LVH progression and the improvement of nutritional status are critical for preventing cardiovascular complications even in non-dialysis patients. |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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27169395 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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532 |
6804.pdf (1.7 MB)
