| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2017-09-20 |
| タイトル |
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タイトル |
Gli2 protein expression level is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
杉山, 祥晃
笹嶋, 順平
水上, 裕輔
小泉, 一也
河本, 徹
小野, 裕介
唐崎, 秀則
田邊, 裕貴
藤谷, 幹浩
高後, 裕
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| 著者 ローマ字 |
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Sugiyama, Yoshiaki |
| 著者 ローマ字 |
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Sasajima, Junpei |
| 著者 ローマ字 |
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Mizukami, Yusuke |
| 著者 ローマ字 |
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Koizumi, Kazuya |
| 著者 ローマ字 |
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Kawamoto, Toru |
| 著者 ローマ字 |
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Ono, Yusuke |
| 著者 ローマ字 |
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Karasaki, Hidenori |
| 著者 ローマ字 |
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Tanabe, Hiroki |
| 著者 ローマ字 |
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Fujiya, Mikihiro |
| 著者 ローマ字 |
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Kohgo, Yutaka |
| 書誌情報 |
Polish Journal of Pathology
巻 67,
号 2,
p. 136-144,
発行日 2016-06-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1233-9687 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.5114/pjp.2016.61449 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID：27543868 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The hedgehog pathway is known to promote proliferation of pancreatic ductal adenocarcinoma (PDA) and has been shown to restrain tumor progression. To understand how hedgehog causes these effects, we sought to carefully examine protein expression of hedgehog signaling components during different tumor stages. Genetically engineered mice, Pdx1-Cre;LSL-KrasG12D and Pdx1-Cre;LSL-KrasG12D;p53lox/+, were utilized to model distinct phases of tumorigenesis, pancreatic intraepithelial neoplasm (PanIN) and PDA. Human pancreatic specimens of intraductal papillary mucinous neoplasm (IPMN) and PDA were also employed. PanIN and IPMN lesions highly express Sonic Hedgehog, at a level that is slightly higher than that observed in PDA. GLI2 protein is also expressed in both PanIN/IPMN and PDA. Although there was no difference in the nuclear staining, the cytoplasmic GLI2 level in PDA was modest in comparison to that in PanIN/IPMN. Hedgehog interacting protein was strongly expressed in the precursors, whereas the level in PDA was significantly attenuated. There were no differences in expression of Patched1 at early and late stages. Finally, a strong correlation between Sonic Hedgehog and GLI2 staining was found in both human and murine pancreatic tumors. The results indicate that the GLI2 protein level could serve as a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/) |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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27543868 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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616 |
6795.pdf (422.8 kB)
