{"created":"2023-06-19T11:24:56.412846+00:00","id":5729,"links":{},"metadata":{"_buckets":{"deposit":"1bce59cb-6cbd-4e1e-a19d-b3a19c97ba53"},"_deposit":{"created_by":1,"id":"5729","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5729"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005729","sets":["7","7:24"]},"author_link":["18020","18021","18026","18018","18023","18027","18019","18022","18024","18025"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"144","bibliographicPageStart":"136","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"Polish Journal of Pathology"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：27543868","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The hedgehog pathway is known to promote proliferation of pancreatic ductal adenocarcinoma (PDA) and has been shown to restrain tumor progression. To understand how hedgehog causes these effects, we sought to carefully examine protein expression of hedgehog signaling components during different tumor stages. Genetically engineered mice, Pdx1-Cre;LSL-KrasG12D and Pdx1-Cre;LSL-KrasG12D;p53lox/+, were utilized to model distinct phases of tumorigenesis, pancreatic intraepithelial neoplasm (PanIN) and PDA. Human pancreatic specimens of intraductal papillary mucinous neoplasm (IPMN) and PDA were also employed. PanIN and IPMN lesions highly express Sonic Hedgehog, at a level that is slightly higher than that observed in PDA. GLI2 protein is also expressed in both PanIN/IPMN and PDA. Although there was no difference in the nuclear staining, the cytoplasmic GLI2 level in PDA was modest in comparison to that in PanIN/IPMN. Hedgehog interacting protein was strongly expressed in the precursors, whereas the level in PDA was significantly attenuated. There were no differences in expression of Patched1 at early and late stages. Finally, a strong correlation between Sonic Hedgehog and GLI2 staining was found in both human and murine pancreatic tumors. The results indicate that the GLI2 protein level could serve as a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/)","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5114/pjp.2016.61449","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1233-9687","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"27543868"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"614"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"616"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Sugiyama, Yoshiaki"},{"subitem_text_value":"Sasajima, Junpei"},{"subitem_text_value":"Mizukami, Yusuke"},{"subitem_text_value":"Koizumi, Kazuya"},{"subitem_text_value":"Kawamoto, Toru"},{"subitem_text_value":"Ono, Yusuke"},{"subitem_text_value":"Karasaki, Hidenori"},{"subitem_text_value":"Tanabe, Hiroki"},{"subitem_text_value":"Fujiya, Mikihiro"},{"subitem_text_value":"Kohgo, Yutaka"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉山, 祥晃"},{"creatorName":"スギヤマ, ヨシアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笹嶋, 順平"},{"creatorName":"ササジマ, ジュンペイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"水上, 裕輔"},{"creatorName":"ミズカミ, ユウスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小泉, 一也"},{"creatorName":"コイズミ, カズヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河本, 徹"},{"creatorName":"カワモト, トオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野, 裕介"},{"creatorName":"オノ, ユウスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"唐崎, 秀則"},{"creatorName":"カラサキ, ヒデノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田邊, 裕貴"},{"creatorName":"タナベ, ヒロキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤谷, 幹浩"},{"creatorName":"フジヤ, ミキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高後, 裕"},{"creatorName":"コウゴ, ユタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18027","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6795.pdf","filesize":[{"value":"422.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6795.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5729/files/6795.pdf"},"version_id":"37dcddf7-40cd-4604-9ef6-ea31b5f58ffa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Gli2 protein expression level is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Gli2 protein expression level is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms"}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-20"},"publish_date":"2017-09-20","publish_status":"0","recid":"5729","relation_version_is_last":true,"title":["Gli2 protein expression level is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:14:04.741265+00:00"}