| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2017-09-12 |
| タイトル |
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タイトル |
Comparison of the serological tests ICT and ELISA for the diagnosis of alveolar echinococcosis in France. |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
alveolar echinococcosis |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
diagnosis |
| キーワード |
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主題Scheme |
Other |
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キーワード |
rEm18 |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
immunochromatography |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
rapid test |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
rEm18-ELISA and Em2-Em18-ELISA tests |
| 資源タイプ |
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|
資源タイプ |
journal article |
| 著者 |
Jenny, Knapp
迫, 康仁
Frédéric, Grenouillet
Solange, Bresson-Hadni
Carine, Richou
Houssein, Gbaguidi-Haore
伊藤, 亮
Laurence, Millon
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| 著者 ローマ字 |
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| 著者 ローマ字 |
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Sako, Yasuhito |
| 著者 ローマ字 |
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| 著者 ローマ字 |
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| 著者 ローマ字 |
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| 著者 ローマ字 |
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| 著者 ローマ字 |
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Ito, Akira |
| 書誌情報 |
Parasite
号 21,
p. 1-6,
発行日 2014-07-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1252-607X |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1051/parasite/2014037. |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID：25058754 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Serological diagnosis of alveolar echinococcosis (AE) is a key element for efficient patient treatment management. A rapid immunochromatography test kit (ICT) using the recombinant Em18 antigen (rEm18) was recently developed. The aim of our study was to assess this test on a panel of sera from French patients with alveolar echinococcosis and control patients. In a blind test, a total of 112 serum samples were tested including samples of AE (n = 30), cystic echinococcosis [CE] (n = 15), and polycystic echinococcosis [PE] (n = 1). For the comparison, 66 sera from patients with hepatocarcinoma, fascioliasis, toxocariasis, Caroli's disease, or autoimmune chronic active hepatitis were used. The diagnostic test sets we used were the rEm18-ICT and two validated ELISAs with rEm18 and Em2-Em18 antigens, respectively. For the ICT, 27/30 sera from AE patients, 4/15 sera from CE patients and the PE patient serum were positive. One serum from the control panel (toxocariasis) was positive for the ICT. The rEm18-ICT sensitivity (90.0%) and specificity (92.7%) for detection of Em18-specific antibodies confirmed it as a relevant tool for AE diagnosis. The rEm18-ELISA had a sensitivity of 86.7% and specificity of 91.5%, and the Em2-Em18-ELISA had a sensitivity of 96.7% and specificity of 87.8%. However, when AE patient sera are recorded as weak in intensity with the ICT, we recommend a double reading and use of a reference sample if the ICT is used for patient follow-up. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution License |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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25058754 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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587 |
6784.pdf (664.6 kB)
