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Glial Endothelin-1 Regulates Retinal Blood Flow During Hyperoxia in Cats
https://asahikawa-med.repo.nii.ac.jp/records/5712
https://asahikawa-med.repo.nii.ac.jp/records/5712e5c9aa52-bebc-43e2-9b76-94b2d490dc25
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6777.pdf (886.2 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2017-09-08 | |||||
| タイトル | ||||||
| タイトル | Glial Endothelin-1 Regulates Retinal Blood Flow During Hyperoxia in Cats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
宋, 勇錫
× 宋, 勇錫× 長岡, 泰司× 善岡, 尊文× 大野, 晋治× 和田, 剛成× 中林, 征吾× 谷, 智文× 吉田, 晃敏 |
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| 著者 ローマ字 | ||||||
| 値 | Song, Young-Seok | |||||
| 著者 ローマ字 | ||||||
| 値 | Nagaoka, Taiji | |||||
| 著者 ローマ字 | ||||||
| 値 | Yoshioka, Takafumi | |||||
| 著者 ローマ字 | ||||||
| 値 | Ono, Shinji | |||||
| 著者 ローマ字 | ||||||
| 値 | Wada, Takanari | |||||
| 著者 ローマ字 | ||||||
| 値 | Nakabayashi, Seiko | |||||
| 著者 ローマ字 | ||||||
| 値 | Tani, Tomofumi | |||||
| 著者 ローマ字 | ||||||
| 値 | Yoshida, Akitoshi | |||||
| 書誌情報 |
Investigative Ophthalmology and Visual Science 巻 57, 号 11, p. 4962-4969, 発行日 2016-09-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0146-0404 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1167/iovs.16-19599 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID：27654423 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: \nTo investigate the role of endothelin-1 (ET-1) in retinal glial cells in regulating retinal blood flow (RBF) during hyperoxia in cats. Methods: \nWe measured the vessel diameter (D), blood velocity (V), and blood flow (F) simultaneously in first-order retinal arterioles using a laser Doppler velocimetry system. The animals were under general anesthesia during hyperoxia (100% oxygen) for 10 minutes 24 hours after intravitreal injection of L-2-aminoadipic acid (LAA), a gliotoxic compound, or diluted hydrochloric acid (0.01 N) used as the vehicle control. We also measured the changes in the RBF after intravitreal injection of BQ-123, a specific ET type A receptor antagonist, in LAA-treated eyes. To examine if endothelin-converting enzyme-1 (ECE-1), as an ET-1-generating enzyme located in retinal glial cells, immunohistochemical examinations with costaining of antiglial fibrillary acidic protein (GFAP) antibody and anti-ECE-1 antibody were performed in whole-mount retinas. Results: \nDuring hyperoxia, the decreases in D, V, and F in response to hyperoxia were attenuated significantly (P < 0.01 for all comparisons) in the LAA-treated eyes compared with the vehicle control (LAA, D, -8.5 ± 1.5%; V, -13.8 ± 1.5%; F, -27.8 ± 3.0% versus vehicle control, D, -16.8 ± 1.3%; V, -26.3 ± 2.0%; F, -48.9 ± 2.4%). In LAA-treated eyes, intravitreal injections of BQ-123 did not change the rate of hyperoxia-induced RBF compared to LAA-treated eyes. The anti-ECE-1 antibody was costained with anti-GFAP antibody in the whole-mount retinas. Conclusions: \nThe current findings suggest that retinal glial ET-1 may play an important role in regulating RBF during hyperoxia in cats. |
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| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This work is licensed under a Creative Commons Attribution 4.0 International License. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 27654423 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 534 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 574 | |||||
