{"created":"2023-06-19T11:24:55.274847+00:00","id":5712,"links":{},"metadata":{"_buckets":{"deposit":"920888a0-a09e-4167-84ee-1ccac39d0e36"},"_deposit":{"created_by":1,"id":"5712","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5712"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005712","sets":["7","7:24"]},"author_link":["17891","17886","17892","17887","17888","17889","17885","17890"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"4969","bibliographicPageStart":"4962","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Investigative Ophthalmology and Visual Science"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：27654423","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose:\n\\nTo investigate the role of endothelin-1 (ET-1) in retinal glial cells in regulating retinal blood flow (RBF) during hyperoxia in cats.\nMethods:\n\\nWe measured the vessel diameter (D), blood velocity (V), and blood flow (F) simultaneously in first-order retinal arterioles using a laser Doppler velocimetry system. The animals were under general anesthesia during hyperoxia (100% oxygen) for 10 minutes 24 hours after intravitreal injection of L-2-aminoadipic acid (LAA), a gliotoxic compound, or diluted hydrochloric acid (0.01 N) used as the vehicle control. We also measured the changes in the RBF after intravitreal injection of BQ-123, a specific ET type A receptor antagonist, in LAA-treated eyes. To examine if endothelin-converting enzyme-1 (ECE-1), as an ET-1-generating enzyme located in retinal glial cells, immunohistochemical examinations with costaining of antiglial fibrillary acidic protein (GFAP) antibody and anti-ECE-1 antibody were performed in whole-mount retinas.\nResults:\n\\nDuring hyperoxia, the decreases in D, V, and F in response to hyperoxia were attenuated significantly (P < 0.01 for all comparisons) in the LAA-treated eyes compared with the vehicle control (LAA, D, -8.5 ± 1.5%; V, -13.8 ± 1.5%; F, -27.8 ± 3.0% versus vehicle control, D, -16.8 ± 1.3%; V, -26.3 ± 2.0%; F, -48.9 ± 2.4%). In LAA-treated eyes, intravitreal injections of BQ-123 did not change the rate of hyperoxia-induced RBF compared to LAA-treated eyes. The anti-ECE-1 antibody was costained with anti-GFAP antibody in the whole-mount retinas.\nConclusions:\n\\nThe current findings suggest that retinal glial ET-1 may play an important role in regulating RBF during hyperoxia in cats.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This work is licensed under a Creative Commons Attribution 4.0 International License.","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1167/iovs.16-19599","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0146-0404","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"27654423"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"534"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"574"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Song, Young-Seok"},{"subitem_text_value":"Nagaoka, Taiji"},{"subitem_text_value":"Yoshioka, Takafumi"},{"subitem_text_value":"Ono, Shinji"},{"subitem_text_value":"Wada, Takanari"},{"subitem_text_value":"Nakabayashi, Seiko"},{"subitem_text_value":"Tani, Tomofumi"},{"subitem_text_value":"Yoshida, Akitoshi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宋, 勇錫"},{"creatorName":"ソン, ヨンソ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長岡, 泰司"},{"creatorName":"ナガオカ, タイジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"善岡, 尊文"},{"creatorName":"ヨシオカ, タカフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野, 晋治"},{"creatorName":"オオノ, シンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17888","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和田, 剛成"},{"creatorName":"ワダ, タカナリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中林, 征吾"},{"creatorName":"ナカバヤシ, セイゴ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷, 智文"},{"creatorName":"タニ, トモフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17891","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 晃敏"},{"creatorName":"ヨシダ, アキトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17892","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6777.pdf","filesize":[{"value":"886.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6777.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5712/files/6777.pdf"},"version_id":"28ef364c-e57a-4833-ac6d-004a8fda6f2c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Glial Endothelin-1 Regulates Retinal Blood Flow During Hyperoxia in Cats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Glial Endothelin-1 Regulates Retinal Blood Flow During Hyperoxia in Cats"}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-08"},"publish_date":"2017-09-08","publish_status":"0","recid":"5712","relation_version_is_last":true,"title":["Glial Endothelin-1 Regulates Retinal Blood Flow During Hyperoxia in Cats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:14:34.744402+00:00"}