| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2016-10-20 |
| タイトル |
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タイトル |
The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity. |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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キーワード |
3MC syndrome |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Collagen |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Collectin |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Complement |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Embryogenesis |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Innate immunity |
| キーワード |
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主題Scheme |
Other |
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キーワード |
MASP |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Microbes |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Scavenger receptor |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
Soren, W.K Hansen
大谷, 克城
Nitai, Roy
若宮, 伸隆
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| 著者 ローマ字 |
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| 著者 ローマ字 |
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Ohtani, Katsuki |
| 著者 ローマ字 |
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| 著者 ローマ字 |
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Wakamiya, Nobutaka |
| 書誌情報 |
Immunobiology
巻 221,
号 10,
p. 1058-1067,
発行日 2016-10-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0171-2985 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.imbio.2016.05.012 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID:27377710 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Both the complement system and collectins play important roles in our innate immune system. The collectins, which are characterized by their inclusion of a collagen-like region and a calcium-dependent carbohydrate recognition domain, are pattern recognition molecules and include the well characterized proteins mannan-binding lectin (MBL) and the surfactant proteins SP-A/-D. Collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1) and collectin placenta 1 (CL-P1) are the most recently discovered collectins. Although their function is still under investigation, accumulating information suggests that CL-L1, CL-K1 and CL-P1 play important roles in host defense by recognizing a variety of microorganisms and interacting with effector proteins, including complement components. The recent establishment of the existence of CL-K1 in the circulation in form of heteromeric complexes with CL-L1 (known as CL-LK) and its activation of the lectin pathway via MASPs, drew new attention in the complement biology, which was further strengthened by the observed interactions between CL-P1 and CRP-C1q-factor H or properdin. Deficiency of either CL-K1 or MASP-3 has been demonstrated in 3MC syndrome patients with developmental abnormalities, showing that lectin pathway components, regulation and/or activation are essential during the embryonic development; another feature that they most likely share CL-P1. Herein, we discuss the recent characteristics and roles of the collectins CL-L1, CL-K1 and CL-P1 in the complement system, in innate immunity and their possible association with disease development and pathogenesis. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
CC-BY-NC-ND
epub 2016.6 |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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27377710 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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554 |
6561.pdf (929.4 kB)
