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The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity.
https://asahikawa-med.repo.nii.ac.jp/records/5696
https://asahikawa-med.repo.nii.ac.jp/records/569603f0b032-aa52-4082-917f-609fb10b7435
名前 / ファイル | ライセンス | アクション |
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6561.pdf (929.4 kB)
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2016-10-20 | |||||
タイトル | ||||||
タイトル | The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | 3MC syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Collagen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Collectin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Complement | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Embryogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Innate immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | MASP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Microbes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Scavenger receptor | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Soren, W.K Hansen
× Soren, W.K Hansen× 大谷, 克城× Nitai, Roy× 若宮, 伸隆 |
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著者 ローマ字 | ||||||
著者 ローマ字 | ||||||
Ohtani, Katsuki | ||||||
著者 ローマ字 | ||||||
著者 ローマ字 | ||||||
Wakamiya, Nobutaka | ||||||
書誌情報 |
Immunobiology 巻 221, 号 10, p. 1058-1067, 発行日 2016-10-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0171-2985 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.imbio.2016.05.012 | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:27377710 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Both the complement system and collectins play important roles in our innate immune system. The collectins, which are characterized by their inclusion of a collagen-like region and a calcium-dependent carbohydrate recognition domain, are pattern recognition molecules and include the well characterized proteins mannan-binding lectin (MBL) and the surfactant proteins SP-A/-D. Collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1) and collectin placenta 1 (CL-P1) are the most recently discovered collectins. Although their function is still under investigation, accumulating information suggests that CL-L1, CL-K1 and CL-P1 play important roles in host defense by recognizing a variety of microorganisms and interacting with effector proteins, including complement components. The recent establishment of the existence of CL-K1 in the circulation in form of heteromeric complexes with CL-L1 (known as CL-LK) and its activation of the lectin pathway via MASPs, drew new attention in the complement biology, which was further strengthened by the observed interactions between CL-P1 and CRP-C1q-factor H or properdin. Deficiency of either CL-K1 or MASP-3 has been demonstrated in 3MC syndrome patients with developmental abnormalities, showing that lectin pathway components, regulation and/or activation are essential during the embryonic development; another feature that they most likely share CL-P1. Herein, we discuss the recent characteristics and roles of the collectins CL-L1, CL-K1 and CL-P1 in the complement system, in innate immunity and their possible association with disease development and pathogenesis. | |||||
注記 | ||||||
内容記述タイプ | Other | |||||
注記 | CC-BY-NC-ND epub 2016.6 |
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資源タイプ | ||||||
内容記述タイプ | Other | |||||
資源タイプ | text | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
27377710 | ||||||
閲覧数(XooNIps) | ||||||
299 | ||||||
ダウンロード数(XooNIps) | ||||||
554 |