{"created":"2023-06-19T11:24:54.451451+00:00","id":5696,"links":{},"metadata":{"_buckets":{"deposit":"6209e7db-e511-4311-9ab1-cd905a2b8f5e"},"_deposit":{"created_by":1,"id":"5696","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5696"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005696","sets":["7","7:24"]},"author_link":["17769","17767","17766","17768"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1067","bibliographicPageStart":"1058","bibliographicVolumeNumber":"221","bibliographic_titles":[{"bibliographic_title":"Immunobiology"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID:27377710"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Both the complement system and collectins play important roles in our innate immune system. The collectins, which are characterized by their inclusion of a collagen-like region and a calcium-dependent carbohydrate recognition domain, are pattern recognition molecules and include the well characterized proteins mannan-binding lectin (MBL) and the surfactant proteins SP-A/-D. Collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1) and collectin placenta 1 (CL-P1) are the most recently discovered collectins. Although their function is still under investigation, accumulating information suggests that CL-L1, CL-K1 and CL-P1 play important roles in host defense by recognizing a variety of microorganisms and interacting with effector proteins, including complement components. The recent establishment of the existence of CL-K1 in the circulation in form of heteromeric complexes with CL-L1 (known as CL-LK) and its activation of the lectin pathway via MASPs, drew new attention in the complement biology, which was further strengthened by the observed interactions between CL-P1 and CRP-C1q-factor H or properdin. Deficiency of either CL-K1 or MASP-3 has been demonstrated in 3MC syndrome patients with developmental abnormalities, showing that lectin pathway components, regulation and/or activation are essential during the embryonic development; another feature that they most likely share CL-P1. Herein, we discuss the recent characteristics and roles of the collectins CL-L1, CL-K1 and CL-P1 in the complement system, in innate immunity and their possible association with disease development and pathogenesis.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"CC-BY-NC-ND\nepub 2016.6","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.imbio.2016.05.012","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0171-2985","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"27377710"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"554"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Ohtani, Katsuki"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Wakamiya, Nobutaka"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Soren, W.K  Hansen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大谷, 克城"},{"creatorName":"オオタニ, カツキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nitai, Roy"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"若宮, 伸隆"},{"creatorName":"ワカミヤ, ノブタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6561.pdf","filesize":[{"value":"929.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6561.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5696/files/6561.pdf"},"version_id":"4c9c3798-1c99-4bab-bf96-de56fc61959a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"3MC syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"Collagen","subitem_subject_scheme":"Other"},{"subitem_subject":"Collectin","subitem_subject_scheme":"Other"},{"subitem_subject":"Complement","subitem_subject_scheme":"Other"},{"subitem_subject":"Embryogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"Innate immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"MASP","subitem_subject_scheme":"Other"},{"subitem_subject":"Microbes","subitem_subject_scheme":"Other"},{"subitem_subject":"Scavenger receptor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-20"},"publish_date":"2016-10-20","publish_status":"0","recid":"5696","relation_version_is_last":true,"title":["The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:15:05.636013+00:00"}