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Macrophage inflammatory protein-2 induced by TNF-alpha plays a pivotal role in concanavalin A-induced liver injury in mice.
https://asahikawa-med.repo.nii.ac.jp/records/569
https://asahikawa-med.repo.nii.ac.jp/records/569059ae9c9-9929-474c-8ce4-ec7ab7c8e2bf
| 名前 / ファイル | ライセンス | アクション |
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708.pdf (286.0 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||||||||
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| 公開日 | 2007-08-24 | |||||||||||||||||||||||
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| タイトル | Macrophage inflammatory protein-2 induced by TNF-alpha plays a pivotal role in concanavalin A-induced liver injury in mice. | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 著者 |
中村, 公英
× 中村, 公英
× Okada, M
× Yoneda, M
× Takamoto, S
× Nakade, Y
× Tamori, K
× Aso, K
× Makino, I
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| 著者 ローマ字 | ||||||||||||||||||||||||
| Nakamura, Kimihide | ||||||||||||||||||||||||
| 書誌情報 |
JOURNAL OF HEPATOLOGY 巻 35, 号 2, p. 217-224, 発行日 2001-08-01 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 0168-8278 | |||||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | 10.1016/S0168-8278(01)00109-X | |||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | http://www.sciencedirect.com/science/journal/01688278 | http://www.sciencedirect.com/science/journal/01688278 | |||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Background/Aims: Macrophage inflammatory protein-2 (MIP-2), one of CXC chemokines is involved in the recruitment of neutrophils in several tissue injury. In this study, we investigated a role of MIP-2 in concanavalin A (Con A)-induced liver injury in mice. Methods:Liver injury was induced by intravenous injection of Con A (15 mg/kg) and plasma alanine aminotransferase (ALT), MIP-2 levels were determined and histological assessment of the liver was performed. Anti-mouse MIP-2 antibody was intravenously administered 30 min before Con A injection. Results: Plasma ALT level significantly elevated and reached a maximum at 8 h after Con A injection. Plasma MIP-2 level was also elevated and reached peak value at 2 h after Con A injection. The elevated ALT level by Con A injection was significantly inhibited by MIP-2 antibody. The elevated plasma MIP-2 level after Con A injection was significantly reduced by TNF-a antibody, and MIP-2 was induced in plasma after recombinant TNF-a injection. Hepatic necrosis and infiltration of neutrophils were observed after Con A injection, and these histological changes were attenuated by MIP-2 antibody. Conclusion: These findings suggest that Con A induces TNF-a release, and this TNF-a stimulates MIP-2 induction, at least partially contributing to the liver injury mediated through the recruitment of neutrophils. | |||||||||||||||||||||||
| 注記 | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 注記 | Elsevier , Nakamura, K; Okada, M; Yoneda, M; Takamoto, S; Nakade, Y; Tamori, K; Aso, K; Makino, I, JOURNAL OF HEPATOLOGY, 35(2), 2001, 217-224. \nauthor |
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 資源タイプ | text | |||||||||||||||||||||||
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| 出版タイプ | AM | |||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||||||||
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| 11580144 | ||||||||||||||||||||||||
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| 871 | ||||||||||||||||||||||||
