| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-08-24 |
| タイトル |
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タイトル |
Macrophage inflammatory protein-2 induced by TNF-alpha plays a pivotal role in concanavalin A-induced liver injury in mice. |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
中村, 公英
Okada, M
Yoneda, M
Takamoto, S
Nakade, Y
Tamori, K
Aso, K
Makino, I
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| 著者 ローマ字 |
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Nakamura, Kimihide |
| 書誌情報 |
JOURNAL OF HEPATOLOGY
巻 35,
号 2,
p. 217-224,
発行日 2001-08-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0168-8278 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/S0168-8278(01)00109-X |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/journal/01688278 | http://www.sciencedirect.com/science/journal/01688278 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background/Aims: Macrophage inflammatory protein-2 (MIP-2), one of CXC chemokines is involved in the recruitment of neutrophils in several tissue injury. In this study, we investigated a role of MIP-2 in concanavalin A (Con A)-induced liver injury in mice. Methods:Liver injury was induced by intravenous injection of Con A (15 mg/kg) and plasma alanine aminotransferase (ALT), MIP-2 levels were determined and histological assessment of the liver was performed. Anti-mouse MIP-2 antibody was intravenously administered 30 min before Con A injection. Results: Plasma ALT level significantly elevated and reached a maximum at 8 h after Con A injection. Plasma MIP-2 level was also elevated and reached peak value at 2 h after Con A injection. The elevated ALT level by Con A injection was significantly inhibited by MIP-2 antibody. The elevated plasma MIP-2 level after Con A injection was significantly reduced by TNF-a antibody, and MIP-2 was induced in plasma after recombinant TNF-a injection. Hepatic necrosis and infiltration of neutrophils were observed after Con A injection, and these histological changes were attenuated by MIP-2 antibody. Conclusion: These findings suggest that Con A induces TNF-a release, and this TNF-a stimulates MIP-2 induction, at least partially contributing to the liver injury mediated through the recruitment of neutrophils. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
Elsevier , Nakamura, K; Okada, M; Yoneda, M; Takamoto, S; Nakade, Y; Tamori, K; Aso, K; Makino, I, JOURNAL OF HEPATOLOGY, 35(2), 2001, 217-224.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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11580144 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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871 |
708.pdf (286.0 kB)
