{"created":"2023-06-19T11:20:31.660744+00:00","id":569,"links":{},"metadata":{"_buckets":{"deposit":"782086bc-00d8-4d45-b1f6-80dd361f80a0"},"_deposit":{"created_by":3,"id":"569","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"569"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000569","sets":["7","7:24"]},"author_link":["1113","1114","1115","1116","1117","1118","1119","1120"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"224","bibliographicPageStart":"217","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF HEPATOLOGY"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/01688278 | http://www.sciencedirect.com/science/journal/01688278","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aims: Macrophage inflammatory protein-2 (MIP-2), one of CXC chemokines is involved in the recruitment of neutrophils in several tissue injury. In this study, we investigated a role of MIP-2 in concanavalin A (Con A)-induced liver injury in mice. Methods:Liver injury was induced by intravenous injection of Con A (15 mg/kg) and plasma alanine aminotransferase (ALT), MIP-2 levels were determined and histological assessment of the liver was performed. Anti-mouse MIP-2 antibody was intravenously administered 30 min before Con A injection. Results: Plasma ALT level significantly elevated and reached a maximum at 8 h after Con A injection. Plasma MIP-2 level was also elevated and reached peak value at 2 h after Con A injection. The elevated ALT level by Con A injection was significantly inhibited by MIP-2 antibody. The elevated plasma MIP-2 level after Con A injection was significantly reduced by TNF-a antibody, and MIP-2 was induced in plasma after recombinant TNF-a injection. Hepatic necrosis and infiltration of neutrophils were observed after Con A injection, and these histological changes were attenuated by MIP-2 antibody. Conclusion: These findings suggest that Con A induces TNF-a release, and this TNF-a stimulates MIP-2 induction, at least partially contributing to the liver injury mediated through the recruitment of neutrophils.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Elsevier , Nakamura, K; Okada, M; Yoneda, M; Takamoto, S; Nakade, Y; Tamori, K; Aso, K; Makino, I, JOURNAL OF HEPATOLOGY, 35(2), 2001, 217-224.\n\\nauthor","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/S0168-8278(01)00109-X","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0168-8278","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"11580144"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2463"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"871"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Nakamura, Kimihide"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 公英"},{"creatorName":"ナカムラ, キミヒデ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1113","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, M"}],"nameIdentifiers":[{"nameIdentifier":"1114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoneda, M"}],"nameIdentifiers":[{"nameIdentifier":"1115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamoto, S"}],"nameIdentifiers":[{"nameIdentifier":"1116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakade, Y"}],"nameIdentifiers":[{"nameIdentifier":"1117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamori, K"}],"nameIdentifiers":[{"nameIdentifier":"1118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aso, K"}],"nameIdentifiers":[{"nameIdentifier":"1119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makino, I"}],"nameIdentifiers":[{"nameIdentifier":"1120","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"708.pdf","filesize":[{"value":"286.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"708.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/569/files/708.pdf"},"version_id":"db3bff87-2865-4879-bb54-7e69230535de"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Macrophage inflammatory protein-2 induced by TNF-alpha plays a pivotal role in concanavalin A-induced liver injury in mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Macrophage inflammatory protein-2 induced by TNF-alpha plays a pivotal role in concanavalin A-induced liver injury in mice.","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-08-24"},"publish_date":"2007-08-24","publish_status":"0","recid":"569","relation_version_is_last":true,"title":["Macrophage inflammatory protein-2 induced by TNF-alpha plays a pivotal role in concanavalin A-induced liver injury in mice."],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:29:40.278303+00:00"}