| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-08-24 |
| タイトル |
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|
タイトル |
Effect of central urocortin on carbon tetrachloride-induced acute liver injury in rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
横浜, 吏郎
Yoneda, M
Nakamura, K
Makino, I
|
| 著者 ローマ字 |
|
|
|
Yokohama, Shiro |
| 書誌情報 |
NEUROSCIENCE LETTERS
巻 313,
号 3,
p. 149-152,
発行日 2001-11-01
|
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0304-3940 |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/S0304-3940(01)02268-6 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.science-direct.com/science/journal/03043940 | http://www.science-direct.com/science/journal/03043940 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The effect of intracisternal injection of urocortin, an endogenous ligand for corticotropin-releasing factor (CRF) 2 receptor, on carbon tetrachloride (CCl4)-induced acute liver injury was investigated in rats. Intracisternal injection of urocortin dose-dependently enhanced elevation of serum alanine aminotransferase and aspartate aminotransferase levels induced by CCl4. Intracisternal urocortin also aggravated CCl4-induced histological changes of the liver. The aggravating effect of central urocortin on CCl4-induced acute liver injury was abolished by chemical sympathectomy, but not by vagotomy. These data demonstrate that urocortin acts in the brain to exacerbate acute liver injury through the sympathetic nervous system and suggest a possible involvement of the CRF2 receptor in the central CRF-induced exacerbation of acute liver injury in rats. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Elsevier, Shiro Yokohama, Masashi Yoneda, Kimihide Nakamura, Isao, Makino, NEUROSCIENCE LETTERS, 313(3), 2001, 149-152
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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11682149 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1113 |
707.pdf (230.8 kB)
