{"created":"2023-06-19T11:20:31.614037+00:00","id":568,"links":{},"metadata":{"_buckets":{"deposit":"68cee84e-6952-49df-a774-205479d540df"},"_deposit":{"created_by":3,"id":"568","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"568"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000568","sets":["7","7:24"]},"author_link":["1109","1110","1111","1112"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"152","bibliographicPageStart":"149","bibliographicVolumeNumber":"313","bibliographic_titles":[{"bibliographic_title":"NEUROSCIENCE LETTERS"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.science-direct.com/science/journal/03043940 | http://www.science-direct.com/science/journal/03043940","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of intracisternal injection of urocortin, an endogenous ligand for corticotropin-releasing factor (CRF) 2 receptor, on carbon tetrachloride (CCl4)-induced acute liver injury was investigated in rats. Intracisternal injection of urocortin dose-dependently enhanced elevation of serum alanine aminotransferase and aspartate aminotransferase levels induced by CCl4. Intracisternal urocortin also aggravated CCl4-induced histological changes of the liver. The aggravating effect of central urocortin on CCl4-induced acute liver injury was abolished by chemical sympathectomy, but not by vagotomy. These data demonstrate that urocortin acts in the brain to exacerbate acute liver injury through the sympathetic nervous system and suggest a possible involvement of the CRF2 receptor in the central CRF-induced exacerbation of acute liver injury in rats.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Elsevier, Shiro Yokohama, Masashi Yoneda, Kimihide Nakamura, Isao, Makino, NEUROSCIENCE LETTERS, 313(3), 2001, 149-152\n\\nauthor","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/S0304-3940(01)02268-6","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0304-3940","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"11682149"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2834"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1113"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Yokohama, Shiro"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"横浜, 吏郎"},{"creatorName":"ヨコハマ, シロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1109","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoneda, M"}],"nameIdentifiers":[{"nameIdentifier":"1110","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, K"}],"nameIdentifiers":[{"nameIdentifier":"1111","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makino, I"}],"nameIdentifiers":[{"nameIdentifier":"1112","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"707.pdf","filesize":[{"value":"230.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"707.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/568/files/707.pdf"},"version_id":"67ccebda-9b81-4c6d-9479-43ff4578ee65"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of central urocortin on carbon tetrachloride-induced acute liver injury in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of central urocortin on carbon tetrachloride-induced acute liver injury in rats","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-08-24"},"publish_date":"2007-08-24","publish_status":"0","recid":"568","relation_version_is_last":true,"title":["Effect of central urocortin on carbon tetrachloride-induced acute liver injury in rats"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:33:19.095849+00:00"}