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Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice.
https://asahikawa-med.repo.nii.ac.jp/records/566
https://asahikawa-med.repo.nii.ac.jp/records/5667f047378-57e2-4dea-aecf-3141ed0e31f7
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||||||||||||
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公開日 | 2007-08-24 | |||||||||||||||||||||||||||
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タイトル | Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice. | |||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||
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言語 | eng | |||||||||||||||||||||||||||
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資源タイプ | journal article | |||||||||||||||||||||||||||
著者 |
中村, 公英
× 中村, 公英
× Ito, T
× Yoneda, M
× Takamoto, S
× Nakade, Y
× Okamoto, S
× Okada, M
× Yokohama, S
× Aso, K
× Makino, I
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著者 ローマ字 | ||||||||||||||||||||||||||||
Nakamura, Kimihide | ||||||||||||||||||||||||||||
書誌情報 |
JOURNAL OF HEPATOLOGY 巻 36, 号 6, p. 766-773, 発行日 2002-06-01 |
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収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||
収録物識別子 | 0168-8278 | |||||||||||||||||||||||||||
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関連タイプ | isVersionOf | |||||||||||||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||||||||||||
関連識別子 | 10.1016/S0168-8278(02)00059-4 | |||||||||||||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||||||||||||
内容記述 | http://www.sciencedirect.com/science/journal/01688278 | http://www.sciencedirect.com/science/journal/01688278 | |||||||||||||||||||||||||||
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内容記述タイプ | Abstract | |||||||||||||||||||||||||||
内容記述 | Background/Aims: Recently, we have reported that macrophage inflammatory protein-2 (MIP-2) plays a pivotal role in concanavalin A (Con A)-induced liver injury. In this study, we investigated the effect of antithrombin III (AT-III) on liver damage, and production of MIP-2 and prostacyclin in this model. Methods: Liver injury was induced by intravenous injection of Con A (15 mg/kg) and AT-III was administered (50, 250 and 500 units/kg, iv) 30 min before Con A injection. Plasma levels of alanine aminotransferase (ALT), MIP-2 and 6-keto-prostaglandin F1a (6k-PG-F1a), stable metabolite of prostaglandin I2 (prostacyclin), were determined. Results: The elevated plasma ALT levels 8, 16, 24 h after Con A injection were inhibited by AT-III pretreatment. The elevated plasma MIP-2 levels were significantly inhibited by AT-III pretreatment compared with vehicle treatment. The inhibitory effect of AT-III on plasma ALT and MIP-2 in Con A-induced liver injury was attenuated by indomethacin (5 mg/kg, ip). Plasma concentration of 6k-PG-F1a at 2 h after AT-III injection was significantly elevated compared with baseline and vehicle pretreatment. Conclusion: These findings suggest that AT-III prevents Con A-induced liver injury through an inhibition of MIP-2 release and a production of prostacyclin. | |||||||||||||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||||||||||||
注記 | Elsevier , Nakamura, K. ; Ito, T. ; Yoneda, M. ; Takamoto, S. ; Nakade, Y. ; Okamoto, S. ; Okada, M. ; Yokohama, S. ; Aso, K. ; Makino, I., JOURNAL OF HEPATOLOGY, 36(6), 2002, 766-773. \nauthor |
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内容記述タイプ | Other | |||||||||||||||||||||||||||
資源タイプ | text | |||||||||||||||||||||||||||
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出版タイプ | AM | |||||||||||||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||||||||||||
内容記述 | application/pdf | |||||||||||||||||||||||||||
ID(XooNIps) | ||||||||||||||||||||||||||||
12044526 | ||||||||||||||||||||||||||||
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1543 |
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中村, 公英, Ito, T, Yoneda, M, Takamoto, S, Nakade, Y, Okamoto, S, Okada, M, Yokohama, S, Aso, K, Makino, I, n.d., Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice.: 766–773 p.
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