| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-08-24 |
| タイトル |
|
|
タイトル |
Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
中村, 公英
Ito, T
Yoneda, M
Takamoto, S
Nakade, Y
Okamoto, S
Okada, M
Yokohama, S
Aso, K
Makino, I
|
| 著者 ローマ字 |
|
|
|
Nakamura, Kimihide |
| 書誌情報 |
JOURNAL OF HEPATOLOGY
巻 36,
号 6,
p. 766-773,
発行日 2002-06-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0168-8278 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/S0168-8278(02)00059-4 |
| リンクURL |
|
|
内容記述タイプ |
Other |
|
内容記述 |
http://www.sciencedirect.com/science/journal/01688278 | http://www.sciencedirect.com/science/journal/01688278 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background/Aims: Recently, we have reported that macrophage inflammatory protein-2 (MIP-2) plays a pivotal role in concanavalin A (Con A)-induced liver injury. In this study, we investigated the effect of antithrombin III (AT-III) on liver damage, and production of MIP-2 and prostacyclin in this model. Methods: Liver injury was induced by intravenous injection of Con A (15 mg/kg) and AT-III was administered (50, 250 and 500 units/kg, iv) 30 min before Con A injection. Plasma levels of alanine aminotransferase (ALT), MIP-2 and 6-keto-prostaglandin F1a (6k-PG-F1a), stable metabolite of prostaglandin I2 (prostacyclin), were determined. Results: The elevated plasma ALT levels 8, 16, 24 h after Con A injection were inhibited by AT-III pretreatment. The elevated plasma MIP-2 levels were significantly inhibited by AT-III pretreatment compared with vehicle treatment. The inhibitory effect of AT-III on plasma ALT and MIP-2 in Con A-induced liver injury was attenuated by indomethacin (5 mg/kg, ip). Plasma concentration of 6k-PG-F1a at 2 h after AT-III injection was significantly elevated compared with baseline and vehicle pretreatment. Conclusion: These findings suggest that AT-III prevents Con A-induced liver injury through an inhibition of MIP-2 release and a production of prostacyclin. |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
Elsevier , Nakamura, K. ; Ito, T. ; Yoneda, M. ; Takamoto, S. ; Nakade, Y. ; Okamoto, S. ; Okada, M. ; Yokohama, S. ; Aso, K. ; Makino, I., JOURNAL OF HEPATOLOGY, 36(6), 2002, 766-773.
\nauthor |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
|
|
出版タイプ |
AM |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
12044526 |
| 閲覧数(XooNIps) |
|
| ダウンロード数(XooNIps) |
|
|
|
1543 |
705.pdf (292.7 kB)
