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Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice.

https://asahikawa-med.repo.nii.ac.jp/records/566
https://asahikawa-med.repo.nii.ac.jp/records/566
7f047378-57e2-4dea-aecf-3141ed0e31f7
名前 / ファイル ライセンス アクション
705.pdf 705.pdf (292.7 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2007-08-24
タイトル
タイトル Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice.
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 中村, 公英

× 中村, 公英

中村, 公英

ja-Kana ナカムラ, キミヒデ

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Ito, T

× Ito, T

Ito, T

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Yoneda, M

× Yoneda, M

Yoneda, M

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Takamoto, S

× Takamoto, S

Takamoto, S

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Nakade, Y

× Nakade, Y

Nakade, Y

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Okamoto, S

× Okamoto, S

Okamoto, S

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Okada, M

× Okada, M

Okada, M

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Yokohama, S

× Yokohama, S

Yokohama, S

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Aso, K

× Aso, K

Aso, K

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Makino, I

× Makino, I

Makino, I

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著者 ローマ字
Nakamura, Kimihide
書誌情報 JOURNAL OF HEPATOLOGY

巻 36, 号 6, p. 766-773, 発行日 2002-06-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0168-8278
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/S0168-8278(02)00059-4
リンクURL
内容記述タイプ Other
内容記述 http://www.sciencedirect.com/science/journal/01688278 | http://www.sciencedirect.com/science/journal/01688278
抄録
内容記述タイプ Abstract
内容記述 Background/Aims: Recently, we have reported that macrophage inflammatory protein-2 (MIP-2) plays a pivotal role in concanavalin A (Con A)-induced liver injury. In this study, we investigated the effect of antithrombin III (AT-III) on liver damage, and production of MIP-2 and prostacyclin in this model. Methods: Liver injury was induced by intravenous injection of Con A (15 mg/kg) and AT-III was administered (50, 250 and 500 units/kg, iv) 30 min before Con A injection. Plasma levels of alanine aminotransferase (ALT), MIP-2 and 6-keto-prostaglandin F1a (6k-PG-F1a), stable metabolite of prostaglandin I2 (prostacyclin), were determined. Results: The elevated plasma ALT levels 8, 16, 24 h after Con A injection were inhibited by AT-III pretreatment. The elevated plasma MIP-2 levels were significantly inhibited by AT-III pretreatment compared with vehicle treatment. The inhibitory effect of AT-III on plasma ALT and MIP-2 in Con A-induced liver injury was attenuated by indomethacin (5 mg/kg, ip). Plasma concentration of 6k-PG-F1a at 2 h after AT-III injection was significantly elevated compared with baseline and vehicle pretreatment. Conclusion: These findings suggest that AT-III prevents Con A-induced liver injury through an inhibition of MIP-2 release and a production of prostacyclin.
注記
内容記述タイプ Other
注記 Elsevier , Nakamura, K. ; Ito, T. ; Yoneda, M. ; Takamoto, S. ; Nakade, Y. ; Okamoto, S. ; Okada, M. ; Yokohama, S. ; Aso, K. ; Makino, I., JOURNAL OF HEPATOLOGY, 36(6), 2002, 766-773.
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内容記述タイプ Other
資源タイプ text
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出版タイプ AM
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内容記述 application/pdf
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Cite as

中村, 公英, Ito, T, Yoneda, M, Takamoto, S, Nakade, Y, Okamoto, S, Okada, M, Yokohama, S, Aso, K, Makino, I, n.d., Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice.: 766–773 p.

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