{"created":"2023-06-19T11:20:31.517569+00:00","id":566,"links":{},"metadata":{"_buckets":{"deposit":"6eb1de55-6702-4f26-80a1-9a11404814bb"},"_deposit":{"created_by":3,"id":"566","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"566"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000566","sets":["7","7:24"]},"author_link":["1093","1094","1095","1096","1097","1098","1099","1100","1101","1102"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"773","bibliographicPageStart":"766","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF HEPATOLOGY"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/01688278 | http://www.sciencedirect.com/science/journal/01688278","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aims: Recently, we have reported that macrophage inflammatory protein-2 (MIP-2) plays a pivotal role in concanavalin A (Con A)-induced liver injury. In this study, we investigated the effect of antithrombin III (AT-III) on liver damage, and production of MIP-2 and prostacyclin in this model. Methods: Liver injury was induced by intravenous injection of Con A (15 mg/kg) and AT-III was administered (50, 250 and 500 units/kg, iv) 30 min before Con A injection. Plasma levels of alanine aminotransferase (ALT), MIP-2 and 6-keto-prostaglandin F1a (6k-PG-F1a), stable metabolite of prostaglandin I2 (prostacyclin), were determined. Results: The elevated plasma ALT levels 8, 16, 24 h after Con A injection were inhibited by AT-III pretreatment. The elevated plasma MIP-2 levels were significantly inhibited by AT-III pretreatment compared with vehicle treatment. The inhibitory effect of AT-III on plasma ALT and MIP-2 in Con A-induced liver injury was attenuated by indomethacin (5 mg/kg, ip). Plasma concentration of 6k-PG-F1a at 2 h after AT-III injection was significantly elevated compared with baseline and vehicle pretreatment. Conclusion: These findings suggest that AT-III prevents Con A-induced liver injury through an inhibition of MIP-2 release and a production of prostacyclin.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Elsevier , Nakamura, K. ; Ito, T. ; Yoneda, M. ; Takamoto, S. ; Nakade, Y. ; Okamoto, S. ; Okada, M. ; Yokohama, S. ; Aso, K. ; Makino, I., JOURNAL OF HEPATOLOGY, 36(6), 2002, 766-773.\n\\nauthor","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/S0168-8278(02)00059-4","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0168-8278","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"12044526"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2991"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1543"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Nakamura, Kimihide"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 公英"},{"creatorName":"ナカムラ, キミヒデ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, T"}],"nameIdentifiers":[{"nameIdentifier":"1094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoneda, M"}],"nameIdentifiers":[{"nameIdentifier":"1095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamoto, S"}],"nameIdentifiers":[{"nameIdentifier":"1096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakade, Y"}],"nameIdentifiers":[{"nameIdentifier":"1097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamoto, S"}],"nameIdentifiers":[{"nameIdentifier":"1098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, M"}],"nameIdentifiers":[{"nameIdentifier":"1099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokohama, S"}],"nameIdentifiers":[{"nameIdentifier":"1100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aso, K"}],"nameIdentifiers":[{"nameIdentifier":"1101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makino, I"}],"nameIdentifiers":[{"nameIdentifier":"1102","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"705.pdf","filesize":[{"value":"292.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"705.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/566/files/705.pdf"},"version_id":"85dfa416-b063-463e-880a-24b4b3cc51d5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice.","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-08-24"},"publish_date":"2007-08-24","publish_status":"0","recid":"566","relation_version_is_last":true,"title":["Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice."],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:29:41.381649+00:00"}