ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. Public
  1. Public
  2. 学位論文
  3. 博士論文

Collectin kidney 1 (CL-K1) plays an important role in innate immunity against Streptococcus pneumoniae infection

https://asahikawa-med.repo.nii.ac.jp/records/5659
https://asahikawa-med.repo.nii.ac.jp/records/5659
17fd3f22-7994-44f2-b2fd-6a2ff410e1a5
名前 / ファイル ライセンス アクション
6709.pdf 6709.pdf (499.5 kB)
Item type 学位論文 / Thesis or Dissertation_02(1)
公開日 2017-04-26
タイトル
タイトル Collectin kidney 1 (CL-K1) plays an important role in innate immunity against Streptococcus pneumoniae infection
言語 en
言語
言語 jpn
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_46ec
資源タイプ thesis
著者 黄, 仁秀

× 黄, 仁秀

zh-cn 黄, 仁秀

Search repository
著者 ローマ字
Hwang, Insu
書誌情報 Journal of innate immunity

巻 9, 号 2, p. 217-228, 発行日 2017-01-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 1662-811X
DOI
識別子タイプ DOI
関連識別子 10.1159/000453316
識別番号 その他
内容記述タイプ Other
内容記述 PMID:28068663
学位授与番号
学位授与番号 10107A507
学位授与年月日
学位授与年月日 2017-03-24
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 旭川医科大学
抄録
内容記述タイプ Abstract
内容記述 Collectins are C-type lectins that are involved in innate immunity as pattern recognition molecules. Recently, collectin kidney 1 (CL-K1) has been discovered, and in vitro studies have shown that CL-K1 binds to microbes and activates the lectin complement pathway. However, in vivo functions of CL-K1 against microbes have not been elucidated. To investigate the biological functions of CL-K1, we generated CL-K1 knockout (CL-K1-/-) mice and then performed a Streptococcus pneumoniae infection analysis. First, we found that recombinant human CL-K1 bound to S. pneumoniae in a calcium-dependent manner, and induced complement activation. CL-K1-/- mice sera formed less C3 deposition on S. pneumoniae. Furthermore, immunofluorescence analysis in the wild-type (WT) mice demonstrated that CL-K1 and C3 were localized on S. pneumoniae in infected lungs. CL-K1-/- mice revealed decreased phagocytosis of S. pneumoniae. Consequently, less S. pneumoniae clearance was observed in their lungs. CL-K1-/- mice showed severe pulmonary inflammation and weight loss in comparison with WT mice. Finally, the decreased clearance and severe pulmonary inflammation caused by S. pneumoniae infection might cause higher CL-K1-/- mice lethality. Our results suggest that CL-K1 might play an important role in host protection against S. pneumoniae infection through the activation of the lectin complement pathway.
資源タイプ
内容記述タイプ Other
内容記述 application/pdf
フォーマット
内容記述タイプ Other
内容記述 application/pdf
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-19 12:16:02.033429
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3