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Effects of chronic treatment with cilostazol, a phosphodiesterase 3 inhibitor, on female rat bladder in a partial bladder outlet obstruction model.
https://asahikawa-med.repo.nii.ac.jp/records/5486
https://asahikawa-med.repo.nii.ac.jp/records/5486cc755894-905d-4ca8-81df-d78d43e9a046
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2016-06-07 | |||||
タイトル | ||||||
タイトル | Effects of chronic treatment with cilostazol, a phosphodiesterase 3 inhibitor, on female rat bladder in a partial bladder outlet obstruction model. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
松本, 成史
× 松本, 成史× 渡邊, 成樹× 橋爪, 和純× 和田, 直樹× 堀, 淳一× 北, 雅史× 岩田, 達也× 柿崎, 秀宏 |
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著者 ローマ字 | ||||||
値 | Matsumoto, Seiji | |||||
著者 ローマ字 | ||||||
値 | Watanabe, Masaki | |||||
著者 ローマ字 | ||||||
値 | Hashizume, Kazumi | |||||
著者 ローマ字 | ||||||
値 | Wada, Naoki | |||||
著者 ローマ字 | ||||||
値 | Hori, Junichi | |||||
著者 ローマ字 | ||||||
値 | Kita, Masafumi | |||||
著者 ローマ字 | ||||||
値 | Iwata, Tatsuya | |||||
著者 ローマ字 | ||||||
値 | Kakizaki, Hidehiro | |||||
書誌情報 |
Urology 巻 83, 号 3, p. 675.e7-675.e11, 発行日 2014-03-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0090-4295 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.urology.2013.11.030. | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:24581543 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | OBJECTIVE: \nTo investigate whether bladder dysfunction after bladder outlet obstruction (BOO) could be altered by treatment with cilostazol, a phosphodiesterase 3 inhibitor (PDE3i). METHODS: \nTwelve-week-old female Sprague-Dawley rats were divided into 5 groups: groups 1 and 2, sham-operated rats and groups 3-5, BOO rats. Group 1 and 3 rats were given normal diet, group 2 and 5 rats were given high-dose PDE3i diet, and group 4 rats were given low-dose PDE3i diet. PDE3i was given within diet from the day of surgery. Four weeks after BOO, the bladder was excised and dissected into 4 longitudinal strips for isometric organ-bath assay. Contractile responses of bladder strips to electrical field stimulation (EFS), carbachol, and potassium chloride (KCl) were determined for each group. RESULTS: \nBOO induced a significant increase in bladder weight in groups 3-5 compared with groups 1 and 2. PDE3i treatment did not affect bladder weight in sham or BOO rats. Contractile forces in response to EFS, carbachol, and KCl in group 3 were about 20%-40% of those in group 1. Contractile responses to EFS or KCl in PDE3i-treated BOO rats were not significantly different from those in group 3. Only high dose of PDE3i treatment in BOO rats caused a statistically significant increase in the response to carbachol compared with group 3. CONCLUSION: \nPDE3i has a small but significant protective effect on the contractile dysfunction induced by a 4-week BOO in rats, although the increase in bladder mass was not altered. PDE3i could be a useful protection against contractile dysfunction of the obstructed bladder. |
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注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | CC-BY-NC-ND | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
値 | 24581543 | |||||
閲覧数(XooNIps) | ||||||
値 | 628 | |||||
ダウンロード数(XooNIps) | ||||||
値 | 601 |