{"created":"2023-06-19T11:24:43.623359+00:00","id":5486,"links":{},"metadata":{"_buckets":{"deposit":"db3710fd-c842-4943-9f55-c59b513ec41c"},"_deposit":{"created_by":1,"id":"5486","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5486"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005486","sets":["7","7:24"]},"author_link":["17141","17142","17139","17140","17144","17145","17138","17143"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"675.e11","bibliographicPageStart":"675.e7","bibliographicVolumeNumber":"83","bibliographic_titles":[{"bibliographic_title":"Urology"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID:24581543","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"OBJECTIVE:\n\\nTo investigate whether bladder dysfunction after bladder outlet obstruction (BOO) could be altered by treatment with cilostazol, a phosphodiesterase 3 inhibitor (PDE3i).\nMETHODS:\n\\nTwelve-week-old female Sprague-Dawley rats were divided into 5 groups: groups 1 and 2, sham-operated rats and groups 3-5, BOO rats. Group 1 and 3 rats were given normal diet, group 2 and 5 rats were given high-dose PDE3i diet, and group 4 rats were given low-dose PDE3i diet. PDE3i was given within diet from the day of surgery. Four weeks after BOO, the bladder was excised and dissected into 4 longitudinal strips for isometric organ-bath assay. Contractile responses of bladder strips to electrical field stimulation (EFS), carbachol, and potassium chloride (KCl) were determined for each group.\nRESULTS:\n\\nBOO induced a significant increase in bladder weight in groups 3-5 compared with groups 1 and 2. PDE3i treatment did not affect bladder weight in sham or BOO rats. Contractile forces in response to EFS, carbachol, and KCl in group 3 were about 20%-40% of those in group 1. Contractile responses to EFS or KCl in PDE3i-treated BOO rats were not significantly different from those in group 3. Only high dose of PDE3i treatment in BOO rats caused a statistically significant increase in the response to carbachol compared with group 3.\nCONCLUSION:\n\\nPDE3i has a small but significant protective effect on the contractile dysfunction induced by a 4-week BOO in rats, although the increase in bladder mass was not altered. PDE3i could be a useful protection against contractile dysfunction of the obstructed bladder.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"CC-BY-NC-ND","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.urology.2013.11.030.","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0090-4295","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"24581543"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"628"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"601"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Matsumoto, Seiji"},{"subitem_text_value":"Watanabe, Masaki"},{"subitem_text_value":"Hashizume, Kazumi"},{"subitem_text_value":"Wada, Naoki"},{"subitem_text_value":"Hori, Junichi"},{"subitem_text_value":"Kita, Masafumi"},{"subitem_text_value":"Iwata, Tatsuya"},{"subitem_text_value":"Kakizaki, Hidehiro"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松本, 成史"},{"creatorName":"マツモト, セイジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17138","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡邊, 成樹"},{"creatorName":"ワタナベ, マサキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17139","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋爪, 和純"},{"creatorName":"ハシヅメ, カズミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17140","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和田, 直樹"},{"creatorName":"ワダ, ナオキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17141","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"堀, 淳一"},{"creatorName":"ホリ, ジュンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北, 雅史"},{"creatorName":"キタ, マサフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩田, 達也"},{"creatorName":"イワタ, タツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿崎, 秀宏"},{"creatorName":"カキザキ, ヒデヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17145","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6484.pdf","filesize":[{"value":"806.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6484.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5486/files/6484.pdf"},"version_id":"430e4e6c-4e61-42d5-ba27-ab0a8ed2a4b1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of chronic treatment with cilostazol, a phosphodiesterase 3 inhibitor, on female rat bladder in a partial bladder outlet obstruction model.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of chronic treatment with cilostazol, a phosphodiesterase 3 inhibitor, on female rat bladder in a partial bladder outlet obstruction model."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-06-07"},"publish_date":"2016-06-07","publish_status":"0","recid":"5486","relation_version_is_last":true,"title":["Effects of chronic treatment with cilostazol, a phosphodiesterase 3 inhibitor, on female rat bladder in a partial bladder outlet obstruction model."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:20:12.710000+00:00"}