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Role of Glial Cells in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats
https://asahikawa-med.repo.nii.ac.jp/records/5466
https://asahikawa-med.repo.nii.ac.jp/records/5466729470df-7ac0-48a1-a7bb-9dd4e933a19d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6368.pdf (663.7 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2016-03-24 | |||||
| タイトル | ||||||
| タイトル | Role of Glial Cells in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
宋, 勇錫
× 宋, 勇錫× 長岡, 泰司× 善岡, 尊文× 中林, 征吾× 谷, 智文× 吉田, 晃敏 |
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| 著者 ローマ字 | ||||||
| 値 | Song, Yong-Seok | |||||
| 著者 ローマ字 | ||||||
| 値 | Nagaoka, Taiji | |||||
| 著者 ローマ字 | ||||||
| 値 | Yoshioka, Takafumi | |||||
| 著者 ローマ字 | ||||||
| 値 | Nakabayashi, Seigo | |||||
| 著者 ローマ字 | ||||||
| 値 | Tani, Tomofumi | |||||
| 著者 ローマ字 | ||||||
| 値 | Yoshida, Akitoshi | |||||
| 書誌情報 |
Investigative Ophthalmology and Visual Science 巻 56, 号 12, p. 7551-7559, 発行日 2015-11-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0146-0404 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1167/iovs.15-17676 | |||||
| リンクURL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://iovs.arvojournals.org/article.aspx?articleid=2474149 | http://iovs.arvojournals.org/article.aspx?articleid=2474149 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID:26618647 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: \nTo investigate how glial cells participate in retinal circulation during flicker stimulation in cats. METHODS: \nUsing laser Doppler velocimetry, we measured the vessel diameter and blood velocity simultaneously and calculated the retinal blood flow (RBF) in feline first-order retinal arterioles. Twenty-four hours after intravitreal injections of L-2-aminoadipic acid (LAA), a gliotoxic compound, and the solvent of 0.01 N hydrochloric acid as a control, we examined the changes in RBF in response to 16-Hz flicker stimulation for 3 minutes. We also measured the changes in RBF 2 hours after intravitreal injection of Nω-propyl-L-arginine (L-NPA), a selective neuronal nitric oxide synthase inhibitor, in LAA-treated eyes. To evaluate the effects of LAA on retinal neuronal function, ERGs were monitored. Immunohistochemical examinations were performed. RESULTS: \nIn LAA-treated eyes, histologic changes selectively occurred in retinal glial cells. There were no significant reductions in amplitude or elongation of implicit time in ERG after LAA injections compared with controls. In control eyes, the RBF gradually increased and reached the maximal level (53.5% ± 2.5% increase from baseline) after 2 to 3 minutes of flicker stimulation. In LAA-treated eyes, the increases in RBF during flicker stimulation were attenuated significantly compared with controls. In LAA-treated eyes 2 hours after injection of L-NPA, flicker-evoked increases in RBF decreased significantly compared with LAA-treated eyes. CONCLUSIONS: \nThe current results suggested that increases in RBF in response to flicker stimulation were regulated partly by retinal glial cells. |
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| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 26618647 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 587 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 728 | |||||
