{"created":"2023-06-19T11:24:42.719048+00:00","id":5466,"links":{},"metadata":{"_buckets":{"deposit":"4ef35e1d-f413-476c-9fbb-652b6a151373"},"_deposit":{"created_by":1,"id":"5466","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5466"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005466","sets":["7","7:24"]},"author_link":["17062","17058","17060","17059","17057","17061"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"7559","bibliographicPageStart":"7551","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Investigative Ophthalmology and Visual Science"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://iovs.arvojournals.org/article.aspx?articleid=2474149 | http://iovs.arvojournals.org/article.aspx?articleid=2474149","subitem_description_type":"Other"}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID:26618647","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE:\n\\nTo investigate how glial cells participate in retinal circulation during flicker stimulation in cats.\nMETHODS:\n\\nUsing laser Doppler velocimetry, we measured the vessel diameter and blood velocity simultaneously and calculated the retinal blood flow (RBF) in feline first-order retinal arterioles. Twenty-four hours after intravitreal injections of L-2-aminoadipic acid (LAA), a gliotoxic compound, and the solvent of 0.01 N hydrochloric acid as a control, we examined the changes in RBF in response to 16-Hz flicker stimulation for 3 minutes. We also measured the changes in RBF 2 hours after intravitreal injection of Nω-propyl-L-arginine (L-NPA), a selective neuronal nitric oxide synthase inhibitor, in LAA-treated eyes. To evaluate the effects of LAA on retinal neuronal function, ERGs were monitored. Immunohistochemical examinations were performed.\nRESULTS:\n\\nIn LAA-treated eyes, histologic changes selectively occurred in retinal glial cells. There were no significant reductions in amplitude or elongation of implicit time in ERG after LAA injections compared with controls. In control eyes, the RBF gradually increased and reached the maximal level (53.5% ± 2.5% increase from baseline) after 2 to 3 minutes of flicker stimulation. In LAA-treated eyes, the increases in RBF during flicker stimulation were attenuated significantly compared with controls. In LAA-treated eyes 2 hours after injection of L-NPA, flicker-evoked increases in RBF decreased significantly compared with LAA-treated eyes.\nCONCLUSIONS:\n\\nThe current results suggested that increases in RBF in response to flicker stimulation were regulated partly by retinal glial cells.","subitem_description_type":"Abstract"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1167/iovs.15-17676","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0146-0404","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"26618647"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"587"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"728"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Song, Yong-Seok"},{"subitem_text_value":"Nagaoka, Taiji"},{"subitem_text_value":"Yoshioka, Takafumi"},{"subitem_text_value":"Nakabayashi, Seigo"},{"subitem_text_value":"Tani, Tomofumi"},{"subitem_text_value":"Yoshida, Akitoshi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宋, 勇錫"},{"creatorName":"ソン, ヨンソ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長岡, 泰司"},{"creatorName":"ナガオカ, タイジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"善岡, 尊文"},{"creatorName":"ヨシオカ, タカフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17059","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中林, 征吾"},{"creatorName":"ナカバヤシ, セイゴ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17060","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷, 智文"},{"creatorName":"タニ, トモフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17061","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 晃敏"},{"creatorName":"ヨシダ, アキトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17062","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6368.pdf","filesize":[{"value":"663.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6368.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5466/files/6368.pdf"},"version_id":"1efe37b4-fba8-4f61-aacc-259887261ea0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Role of Glial Cells in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of Glial Cells in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats"}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-24"},"publish_date":"2016-03-24","publish_status":"0","recid":"5466","relation_version_is_last":true,"title":["Role of Glial Cells in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:20:40.771090+00:00"}