| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2015-07-21 |
| タイトル |
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タイトル |
Ninjurin1 Is a Novel Factor to Regulate Angiogenesis Through the Function of Pericytes |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Angiogenesis |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Endothelial cells |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Ninjurin1 |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Pericytes |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
松木, 考樹
鹿原, 真樹
齊藤, 幸裕
島村, 浩平
簑島, 暁帆
西村, 正人
青沼, 達也
竹原, 有史
長谷部, 直幸
川辺, 淳一
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| 著者 ローマ字 |
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Matsuki, Motoki |
| 著者 ローマ字 |
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Kabara, Maki |
| 著者 ローマ字 |
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Saito, Yukihiro |
| 著者 ローマ字 |
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Shimamura, Kohei |
| 著者 ローマ字 |
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Minoshima, Akiho |
| 著者 ローマ字 |
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Nishimura, Masato |
| 著者 ローマ字 |
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Aonuma, Tatsuya |
| 著者 ローマ字 |
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Takehara, Naofumi |
| 著者 ローマ字 |
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Hasebe, Naoyuki |
| 著者 ローマ字 |
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Kawabe, Jun-ichi |
| 書誌情報 |
Circulation Journal
巻 79,
号 6,
p. 1363-1371,
発行日 2015-06-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-9843 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1253/circj.CJ-14-1376. |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID:25766274 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
BACKGROUND:
\nCapillary pericytes (cPCs), the mural cells of microvessels, play an important role in the formation and maintenance of microvessels; however, little is known about the mechanisms of how cPCs regulate angiogenesis. To identify factors that modulate cPC function, genes whose levels were altered in cPCs during neovessel formation were identified through a microarray screen.Methods and Results:Ninjurin1 (nerve injury-induced protein, Ninj1) was selected as a candidate factor for angiogenesis regulation. Ninj1 was expressed in capillary cells including endothelial cells (cECs) and was expressed at a higher level in cPCs. Hypoxia induced the gene expression of Ninj1 in addition of vascular endothelial growth factor (VEGF) in cPCs. When cPCs were co-incubated with a thoracic aorta in a three-dimensional Matrigel system, the length of the EC-tubes sprouting from the aorta was increased. Small interfering RNA-mediated downregulation of Ninj1 in cPCs enhanced these cPCs-mediated angiogenic effects, whereas overexpression of Ninj1 attenuated their effects. The production of angiogenic growth factors, such as VEGF and angiopoietin 1, by cPCs was enhanced by the downregulation of Ninj1, and reduced by the overexpression of Ninj1.
CONCLUSIONS:
\nNinj1 is a novel regulator for the angiogenic effect of PCs. Specifically, Ninj1 negatively regulates the formation of neovessels, that is, the EC-tube, by reducing the trophic effects of cPCs. (Circ J 2015; 79: 1363-1371). |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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25766274 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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817 |
6171.pdf (6.2 MB)
