{"created":"2023-06-19T11:24:31.146699+00:00","id":5250,"links":{},"metadata":{"_buckets":{"deposit":"eda78e26-eadb-4d75-a047-61987437d69b"},"_deposit":{"created_by":1,"id":"5250","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5250"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005250","sets":["7","7:24"]},"author_link":["16419","16413","16421","16416","16412","16420","16415","16414","16418","16417"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1371","bibliographicPageStart":"1363","bibliographicVolumeNumber":"79","bibliographic_titles":[{"bibliographic_title":"Circulation Journal"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID:25766274","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND:\n\\nCapillary pericytes (cPCs), the mural cells of microvessels, play an important role in the formation and maintenance of microvessels; however, little is known about the mechanisms of how cPCs regulate angiogenesis. To identify factors that modulate cPC function, genes whose levels were altered in cPCs during neovessel formation were identified through a microarray screen.Methods and Results:Ninjurin1 (nerve injury-induced protein, Ninj1) was selected as a candidate factor for angiogenesis regulation. Ninj1 was expressed in capillary cells including endothelial cells (cECs) and was expressed at a higher level in cPCs. Hypoxia induced the gene expression of Ninj1 in addition of vascular endothelial growth factor (VEGF) in cPCs. When cPCs were co-incubated with a thoracic aorta in a three-dimensional Matrigel system, the length of the EC-tubes sprouting from the aorta was increased. Small interfering RNA-mediated downregulation of Ninj1 in cPCs enhanced these cPCs-mediated angiogenic effects, whereas overexpression of Ninj1 attenuated their effects. The production of angiogenic growth factors, such as VEGF and angiopoietin 1, by cPCs was enhanced by the downregulation of Ninj1, and reduced by the overexpression of Ninj1.\nCONCLUSIONS:\n\\nNinj1 is a novel regulator for the angiogenic effect of PCs. Specifically, Ninj1 negatively regulates the formation of neovessels, that is, the EC-tube, by reducing the trophic effects of cPCs. (Circ J 2015; 79: 1363-1371).","subitem_description_type":"Abstract"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1253/circj.CJ-14-1376.","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-9843","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"25766274"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"632"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"817"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Matsuki, Motoki"},{"subitem_text_value":"Kabara, Maki"},{"subitem_text_value":"Saito, Yukihiro"},{"subitem_text_value":"Shimamura, Kohei"},{"subitem_text_value":"Minoshima, Akiho"},{"subitem_text_value":"Nishimura, Masato"},{"subitem_text_value":"Aonuma, Tatsuya"},{"subitem_text_value":"Takehara, Naofumi"},{"subitem_text_value":"Hasebe, Naoyuki"},{"subitem_text_value":"Kawabe, Jun-ichi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松木, 考樹"},{"creatorName":"マツキ, モトキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鹿原, 真樹"},{"creatorName":"カバラ, マキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齊藤, 幸裕"},{"creatorName":"サイトウ, ユキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島村, 浩平"},{"creatorName":"シマムラ, コウヘイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"簑島, 暁帆"},{"creatorName":"ミノシマ, アキホ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, 正人"},{"creatorName":"ニシムラ, マサト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青沼, 達也"},{"creatorName":"アオヌマ, タツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹原, 有史"},{"creatorName":"タケハラ, ナオフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷部, 直幸"},{"creatorName":"ハセベ, ナオユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川辺, 淳一"},{"creatorName":"カワベ, ジュンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16421","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6171.pdf","filesize":[{"value":"6.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6171.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5250/files/6171.pdf"},"version_id":"da88dea5-a597-427a-9c23-cd3d7436c193"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Angiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelial cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Ninjurin1","subitem_subject_scheme":"Other"},{"subitem_subject":"Pericytes","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ninjurin1 Is a Novel Factor to Regulate Angiogenesis Through the Function of Pericytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ninjurin1 Is a Novel Factor to Regulate Angiogenesis Through the Function of Pericytes"}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-07-21"},"publish_date":"2015-07-21","publish_status":"0","recid":"5250","relation_version_is_last":true,"title":["Ninjurin1 Is a Novel Factor to Regulate Angiogenesis Through the Function of Pericytes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:26:07.254628+00:00"}