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Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in patients with peripheral arterial disease.
https://asahikawa-med.repo.nii.ac.jp/records/5226
https://asahikawa-med.repo.nii.ac.jp/records/5226cd24cc99-77ed-4953-a918-2bc26b86b05e
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2015-05-25 | |||||
タイトル | ||||||
タイトル | Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in patients with peripheral arterial disease. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PAD | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TCI | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | landiolol hydrochloride | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peripheral arterial disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pharmacokinetic parameters | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pharmacokinetics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | target-controlled infusion | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
国沢, 卓之
× 国沢, 卓之× 山岸, 昭夫× 須野, 学× Nakade, Susumu× Honda, Naoki× 黒澤, 温× 田崎, 嘉一× 岩崎, 寛 |
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著者 ローマ字 | ||||||
値 | Kunisawa, Takayuki | |||||
著者 ローマ字 | ||||||
値 | Yamagishi, Akio | |||||
著者 ローマ字 | ||||||
値 | Suno, Manabu | |||||
著者 ローマ字 | ||||||
著者 ローマ字 | ||||||
著者 ローマ字 | ||||||
値 | Kurosawa, Atsushi | |||||
著者 ローマ字 | ||||||
値 | Tasaki, Yoshikazu | |||||
著者 ローマ字 | ||||||
値 | Iwasaki, Hiroshi | |||||
書誌情報 |
Therapeutics and Clinical Risk Management 巻 11, p. 107-114, 発行日 2015-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1176-6336 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2147/TCRM.S74867 | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:25653534 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: \nWe previously determined the pharmacokinetic (PK) parameters of landiolol in healthy male volunteers and gynecological patients. In this study, we determined the PK parameters of landiolol in patients with peripheral arterial disease. METHODS: \nEight patients scheduled to undergo peripheral arterial surgery were enrolled in the study. After inducing anesthesia, landiolol hydrochloride was administered at target plasma concentrations of 500 and 1,000 ng/mL for 30 minutes each. A total of 112 data points of plasma concentration were collected from the patients and used for the population PK analysis. A population PK model was developed using a nonlinear mixed-effect modeling software program (NONMEM). RESULTS: \nThe patients had markedly decreased heart rates at 2 minutes after initiation of landiolol hydrochloride administration; however, systolic blood pressures were lower than the baseline values at only five time points. The concentration time course of landiolol was best described by a two-compartment model with lag time. The estimates of PK parameters were as follows: total body clearance, 30.7 mL/min/kg; distribution volume of the central compartment, 65.0 mL/kg; intercompartmental clearance, 48.3 mL/min/kg; distribution volume of the peripheral compartment, 54.4 mL/kg; and lag time, 0.633 minutes. The predictive performance of this model was better than that of the previous model. CONCLUSION: \nThe PK parameters of landiolol were best described by a two-compartment model with lag time. Distribution volume of the central compartment and total body clearance of landiolol in patients with peripheral arterial disease were approximately 64% and 84% of those in healthy volunteers, respectively. |
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注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出版社版 オープンアクセス CC BY-NC |
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資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
値 | 25653534 | |||||
閲覧数(XooNIps) | ||||||
値 | 778 | |||||
ダウンロード数(XooNIps) | ||||||
値 | 2350 |