{"created":"2023-06-19T11:24:29.879663+00:00","id":5226,"links":{},"metadata":{"_buckets":{"deposit":"166a5446-96d1-4e02-8f09-0ee35d44bb55"},"_deposit":{"created_by":1,"id":"5226","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5226"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005226","sets":["7","7:24"]},"author_link":["16284","16279","16281","16283","16278","16282","16285","16280"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"114","bibliographicPageStart":"107","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Therapeutics and Clinical Risk Management"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID:25653534","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE:\n\\nWe previously determined the pharmacokinetic (PK) parameters of landiolol in healthy male volunteers and gynecological patients. In this study, we determined the PK parameters of landiolol in patients with peripheral arterial disease.\nMETHODS:\n\\nEight patients scheduled to undergo peripheral arterial surgery were enrolled in the study. After inducing anesthesia, landiolol hydrochloride was administered at target plasma concentrations of 500 and 1,000 ng/mL for 30 minutes each. A total of 112 data points of plasma concentration were collected from the patients and used for the population PK analysis. A population PK model was developed using a nonlinear mixed-effect modeling software program (NONMEM).\nRESULTS:\n\\nThe patients had markedly decreased heart rates at 2 minutes after initiation of landiolol hydrochloride administration; however, systolic blood pressures were lower than the baseline values at only five time points. The concentration time course of landiolol was best described by a two-compartment model with lag time. The estimates of PK parameters were as follows: total body clearance, 30.7 mL/min/kg; distribution volume of the central compartment, 65.0 mL/kg; intercompartmental clearance, 48.3 mL/min/kg; distribution volume of the peripheral compartment, 54.4 mL/kg; and lag time, 0.633 minutes. The predictive performance of this model was better than that of the previous model.\nCONCLUSION:\n\\nThe PK parameters of landiolol were best described by a two-compartment model with lag time. Distribution volume of the central compartment and total body clearance of landiolol in patients with peripheral arterial disease were approximately 64% and 84% of those in healthy volunteers, respectively.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出版社版\nオープンアクセス\nCC BY-NC","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2147/TCRM.S74867","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1176-6336","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"25653534"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"778"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2350"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kunisawa, Takayuki"},{"subitem_text_value":"Yamagishi, Akio"},{"subitem_text_value":"Suno, Manabu"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Kurosawa, Atsushi"},{"subitem_text_value":"Tasaki, Yoshikazu"},{"subitem_text_value":"Iwasaki, Hiroshi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"国沢, 卓之"},{"creatorName":"クニサワ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山岸, 昭夫"},{"creatorName":"ヤマギシ, アキオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須野, 学"},{"creatorName":"スノ, マナブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakade, Susumu"}],"nameIdentifiers":[{"nameIdentifier":"16281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honda, Naoki"}],"nameIdentifiers":[{"nameIdentifier":"16282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黒澤, 温"},{"creatorName":"クロサワ, アツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田崎, 嘉一"},{"creatorName":"タサキ, ヨシカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩崎, 寛"},{"creatorName":"イワサキ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16285","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6127.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6127.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5226/files/6127.pdf"},"version_id":"c7502050-4809-462c-b1a4-e5d30c333ebb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PAD","subitem_subject_scheme":"Other"},{"subitem_subject":"TCI","subitem_subject_scheme":"Other"},{"subitem_subject":"landiolol hydrochloride","subitem_subject_scheme":"Other"},{"subitem_subject":"peripheral arterial disease","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetic parameters","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_scheme":"Other"},{"subitem_subject":"target-controlled infusion","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in patients with peripheral arterial disease.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in patients with peripheral arterial disease."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-25"},"publish_date":"2015-05-25","publish_status":"0","recid":"5226","relation_version_is_last":true,"title":["Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in patients with peripheral arterial disease."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:26:45.209515+00:00"}