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Critical roles of cold shock domain protein A as an endogenous angiogenesis inhibitor in skeletal muscle
https://asahikawa-med.repo.nii.ac.jp/records/4552
https://asahikawa-med.repo.nii.ac.jp/records/45524a0a9ffa-eccf-4eee-b699-9b8a832c7cf3
| 名前 / ファイル | ライセンス | アクション |
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5342.pdf (17.2 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||||||||||
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| 公開日 | 2013-07-24 | |||||||||||||||||||||||||
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| タイトル | Critical roles of cold shock domain protein A as an endogenous angiogenesis inhibitor in skeletal muscle | |||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||||||
| 著者 |
齊藤, 幸裕
× 齊藤, 幸裕
× Nakagami, Hironori
× Azuma, Nobuyoshi
× Hirata, Satoshi
× Sanada, Fumihiro
× Taniyama, Yoshiaki
× Morishita, Ryuichi
× Kaneda, Yasufumi
× Sasajima, Tadahiro
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| 書誌情報 |
Antioxidants & redox signaling 巻 15, 号 8, p. 2109-2120, 発行日 2011-10-01 |
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||||
| 収録物識別子 | 1523-0864 | |||||||||||||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||||
| 関連識別子 | 10.1089/ars.2010.3714 | |||||||||||||||||||||||||
| PubMed番号 | ||||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||||
| 関連識別子 | 21473684 | |||||||||||||||||||||||||
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||||
| 内容記述 | Angiogenesis is regulated by the local balance between angiogenic stimulators and inhibitors and is maintained by muscle-derived angiogenic factors in ischemic tissues. AIMS: Our objectives were to investigate the effect of cold shock domain protein A (CSDA) as an endogenous angiogenesis inhibitor and to develop a novel strategy of therapeutic angiogenesis by blocking CSDA expression. RESULTS: In human skeletal muscle cells, CSDA was upregulated during hypoxia when cells were damaged and apoptosis was induced. CSDA expression could repress the activity of hypoxia inducible factor-1α and nuclear factor κB, because CSDA can competitively bind the hypoxia response element and the nuclear factor κB-binding element. As a result, vascular endothelial growth factor-A, interleukin-6, and interleukin-8 secretions from skeletal muscle cells were decreased. Further, CSDA depletion increased the secretion level of these angiogenic factors. In a hindlimb ischemia model, transfer of short-hairpin RNA targeting CSDA ameliorated ischemia without direct transfer of angiogenic factors. In this ischemic tissue, vascular endothelial growth factor-A, interleukin-6, and CXCL2 protein levels were increased. INNOVATION AND CONCLUSION: CSDA appears to play a critical role as an endogenous angiogenesis inhibitor in skeletal muscle, and RNA interference targeting of CSDA is a promising gene therapy strategy for treating peripheral arterial disease. | |||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||
| 資源タイプ | text | |||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||||||||||
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| 21473684 | ||||||||||||||||||||||||||
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| 563 | ||||||||||||||||||||||||||
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齊藤, 幸裕, Nakagami, Hironori, Azuma, Nobuyoshi, Hirata, Satoshi, Sanada, Fumihiro, Taniyama, Yoshiaki, Morishita, Ryuichi, Kaneda, Yasufumi, Sasajima, Tadahiro, n.d., Critical roles of cold shock domain protein A as an endogenous angiogenesis inhibitor in skeletal muscle: 2109–2120 p.
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