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Critical roles of cold shock domain protein A as an endogenous angiogenesis inhibitor in skeletal muscle
https://asahikawa-med.repo.nii.ac.jp/records/4552
https://asahikawa-med.repo.nii.ac.jp/records/45524a0a9ffa-eccf-4eee-b699-9b8a832c7cf3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
5342.pdf (17.2 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2013-07-24 | |||||
| タイトル | ||||||
| タイトル | Critical roles of cold shock domain protein A as an endogenous angiogenesis inhibitor in skeletal muscle | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
齊藤, 幸裕
× 齊藤, 幸裕× Nakagami, Hironori× Azuma, Nobuyoshi× Hirata, Satoshi× Sanada, Fumihiro× Taniyama, Yoshiaki× Morishita, Ryuichi× Kaneda, Yasufumi× Sasajima, Tadahiro |
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| 書誌情報 |
Antioxidants & redox signaling 巻 15, 号 8, p. 2109-2120, 発行日 2011-10-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1523-0864 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1089/ars.2010.3714 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21473684 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Angiogenesis is regulated by the local balance between angiogenic stimulators and inhibitors and is maintained by muscle-derived angiogenic factors in ischemic tissues. AIMS: Our objectives were to investigate the effect of cold shock domain protein A (CSDA) as an endogenous angiogenesis inhibitor and to develop a novel strategy of therapeutic angiogenesis by blocking CSDA expression. RESULTS: In human skeletal muscle cells, CSDA was upregulated during hypoxia when cells were damaged and apoptosis was induced. CSDA expression could repress the activity of hypoxia inducible factor-1α and nuclear factor κB, because CSDA can competitively bind the hypoxia response element and the nuclear factor κB-binding element. As a result, vascular endothelial growth factor-A, interleukin-6, and interleukin-8 secretions from skeletal muscle cells were decreased. Further, CSDA depletion increased the secretion level of these angiogenic factors. In a hindlimb ischemia model, transfer of short-hairpin RNA targeting CSDA ameliorated ischemia without direct transfer of angiogenic factors. In this ischemic tissue, vascular endothelial growth factor-A, interleukin-6, and CXCL2 protein levels were increased. INNOVATION AND CONCLUSION: CSDA appears to play a critical role as an endogenous angiogenesis inhibitor in skeletal muscle, and RNA interference targeting of CSDA is a promising gene therapy strategy for treating peripheral arterial disease. | |||||
| 言語 | en | |||||
| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Publisher | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 21473684 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 908 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 563 | |||||
