{"created":"2023-06-19T11:23:55.681056+00:00","id":4552,"links":{},"metadata":{"_buckets":{"deposit":"c2fc8bb3-d5e7-4dc0-82c5-f6ab5ecdd408"},"_deposit":{"created_by":3,"id":"4552","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4552"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004552","sets":["7","7:24"]},"author_link":["14141","14142","14143","14144","14145","14146","14147","14148","14149"],"control_number":"4552","item_1716186501932":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"21473684","subitem_relation_type_select":"PMID"}}]},"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"2120","bibliographicPageStart":"2109","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Antioxidants & redox signaling"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Angiogenesis is regulated by the local balance between angiogenic stimulators and inhibitors and is maintained by muscle-derived angiogenic factors in ischemic tissues. AIMS: Our objectives were to investigate the effect of cold shock domain protein A (CSDA) as an endogenous angiogenesis inhibitor and to develop a novel strategy of therapeutic angiogenesis by blocking CSDA expression. RESULTS: In human skeletal muscle cells, CSDA was upregulated during hypoxia when cells were damaged and apoptosis was induced. CSDA expression could repress the activity of hypoxia inducible factor-1α and nuclear factor κB, because CSDA can competitively bind the hypoxia response element and the nuclear factor κB-binding element. As a result, vascular endothelial growth factor-A, interleukin-6, and interleukin-8 secretions from skeletal muscle cells were decreased. Further, CSDA depletion increased the secretion level of these angiogenic factors. In a hindlimb ischemia model, transfer of short-hairpin RNA targeting CSDA ameliorated ischemia without direct transfer of angiogenic factors. In this ischemic tissue, vascular endothelial growth factor-A, interleukin-6, and CXCL2 protein levels were increased. INNOVATION AND CONCLUSION: CSDA appears to play a critical role as an endogenous angiogenesis inhibitor in skeletal muscle, and RNA interference targeting of CSDA is a promising gene therapy strategy for treating peripheral arterial disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Publisher","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1089/ars.2010.3714","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1523-0864","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"21473684"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"908"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"563"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"齊藤, 幸裕","creatorNameLang":"ja"},{"creatorName":"サイトウ, ユキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"14141","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakagami, Hironori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Azuma, Nobuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirata, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sanada, Fumihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taniyama, Yoshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morishita, Ryuichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaneda, Yasufumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasajima, Tadahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14149","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"5342.pdf","filesize":[{"value":"17.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"5342.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4552/files/5342.pdf"},"version_id":"0d4bc078-78c1-40fb-b66a-6074f55821cc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Critical roles of cold shock domain protein A as an endogenous angiogenesis inhibitor in skeletal muscle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Critical roles of cold shock domain protein A as an endogenous angiogenesis inhibitor in skeletal muscle","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-07-24"},"publish_date":"2013-07-24","publish_status":"0","recid":"4552","relation_version_is_last":true,"title":["Critical roles of cold shock domain protein A as an endogenous angiogenesis inhibitor in skeletal muscle"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-08-02T08:07:01.215861+00:00"}