| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2013-07-01 |
| タイトル |
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タイトル |
Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
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主題Scheme |
Other |
|
キーワード |
tryptophan, TDO-deficient mice, 0.06% L-Trp diet, wild-type mice |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
Maeta, Akihiro
Fukuwatari, Tsutomu
Funakoshi, Hiroshi
Nakamura, Toshikazu
Shibata, Katsumi
|
| 書誌情報 |
International Journal of Tryptophan Research
p. 1-11,
発行日 2013-06-01
|
| ISSN |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1178-6469 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
We hypothesized that the requirements of essential nutrients are dependent upon catabolic abilities. Mice lacking L-tryptophan 2,3-dioxygenase (TDO) are available. The body concentration of L-tryptophan (L-Trp) has been reported to be higher in TDO-deficient mice than in wild-type (WT) mice. We examined the requirement of an appropriate L-Trp level for TDO-deficient mice using several biomarkers. TDO-deficient mice were fed a 10% amino-acid mixture diet containing 0.06%, 0.08%, and 0.17% L-Trp. WT mice fed a 0.17% Trp diet (standard diet) were used as control mice. The concentrations of L-Trp and its metabolites via serotonin were higher in TDO-deficient mice fed the 0.17% L-Trp diet than in WT mice fed the standard diet, but the concentrations were almost identical between TDO-deficient mice fed the 0.06% L-Trp diet and WT mice fed the standard diet. Therefore, as hypothesized, requirements of essential nutrients are dependent on catabolic abilities. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Publisher |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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IJTR2013-6-1 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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683 |
5305.pdf (652.0 kB)
