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Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice
https://asahikawa-med.repo.nii.ac.jp/records/4515
https://asahikawa-med.repo.nii.ac.jp/records/4515152b7b8c-ef1b-4ada-9669-83ce6ed46b2b
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2013-07-01 | |||||
タイトル | ||||||
タイトル | Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tryptophan, TDO-deficient mice, 0.06% L-Trp diet, wild-type mice | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Maeta, Akihiro
× Maeta, Akihiro× Fukuwatari, Tsutomu× Funakoshi, Hiroshi× Nakamura, Toshikazu× Shibata, Katsumi |
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書誌情報 |
International Journal of Tryptophan Research p. 1-11, 発行日 2013-06-01 |
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ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1178-6469 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We hypothesized that the requirements of essential nutrients are dependent upon catabolic abilities. Mice lacking L-tryptophan 2,3-dioxygenase (TDO) are available. The body concentration of L-tryptophan (L-Trp) has been reported to be higher in TDO-deficient mice than in wild-type (WT) mice. We examined the requirement of an appropriate L-Trp level for TDO-deficient mice using several biomarkers. TDO-deficient mice were fed a 10% amino-acid mixture diet containing 0.06%, 0.08%, and 0.17% L-Trp. WT mice fed a 0.17% Trp diet (standard diet) were used as control mice. The concentrations of L-Trp and its metabolites via serotonin were higher in TDO-deficient mice fed the 0.17% L-Trp diet than in WT mice fed the standard diet, but the concentrations were almost identical between TDO-deficient mice fed the 0.06% L-Trp diet and WT mice fed the standard diet. Therefore, as hypothesized, requirements of essential nutrients are dependent on catabolic abilities. | |||||
言語 | en | |||||
注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Publisher | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
値 | IJTR2013-6-1 | |||||
閲覧数(XooNIps) | ||||||
値 | 1075 | |||||
ダウンロード数(XooNIps) | ||||||
値 | 683 |