{"created":"2023-06-19T11:23:53.798285+00:00","id":4515,"links":{},"metadata":{"_buckets":{"deposit":"aedef8d4-ea27-49fa-b776-d9f6d719a478"},"_deposit":{"created_by":3,"id":"4515","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4515"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004515","sets":["7","7:24"]},"author_link":["14002","14003","14004","14005","14006"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"11","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"International Journal of Tryptophan Research"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We hypothesized that the requirements of essential nutrients are dependent upon catabolic abilities. Mice lacking L-tryptophan 2,3-dioxygenase (TDO) are available. The body concentration of L-tryptophan (L-Trp) has been reported to be higher in TDO-deficient mice than in wild-type (WT) mice. We examined the requirement of an appropriate L-Trp level for TDO-deficient mice using several biomarkers. TDO-deficient mice were fed a 10% amino-acid mixture diet containing 0.06%, 0.08%, and 0.17% L-Trp. WT mice fed a 0.17% Trp diet (standard diet) were used as control mice. The concentrations of L-Trp and its metabolites via serotonin were higher in TDO-deficient mice fed the 0.17% L-Trp diet than in WT mice fed the standard diet, but the concentrations were almost identical between TDO-deficient mice fed the 0.06% L-Trp diet and WT mice fed the standard diet. Therefore, as hypothesized, requirements of essential nutrients are dependent on catabolic abilities.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Publisher","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1178-6469","subitem_source_identifier_type":"EISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"IJTR2013-6-1"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1075"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"683"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maeta, Akihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuwatari, Tsutomu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Funakoshi, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Toshikazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Katsumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14006","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"5305.pdf","filesize":[{"value":"652.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"5305.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4515/files/5305.pdf"},"version_id":"6b4095d2-a8b1-4dda-8d85-6723c61832a6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"tryptophan, TDO-deficient mice, 0.06% L-Trp diet, wild-type mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-07-01"},"publish_date":"2013-07-01","publish_status":"0","recid":"4515","relation_version_is_last":true,"title":["Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T08:39:21.441031+00:00"}