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Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model

https://asahikawa-med.repo.nii.ac.jp/records/4310
https://asahikawa-med.repo.nii.ac.jp/records/4310
a8d394a9-66ae-41d1-b1b7-4e3907991b95
名前 / ファイル ライセンス アクション
5065.pdf 5065.pdf (182.5 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2013-02-26
タイトル
タイトル Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model
言語 en
言語
言語 eng
キーワード
主題Scheme Other
キーワード Oxicam
キーワード
主題Scheme Other
キーワード non-steroidal anti-inflammatory drugs (NSAIDs)
キーワード
主題Scheme Other
キーワード Neuroprotection
キーワード
主題Scheme Other
キーワード Parkinson’s disease (PD)
キーワード
主題Scheme Other
キーワード Akt
キーワード
主題Scheme Other
キーワード 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
資源タイプ
資源タイプ journal article
著者 田崎, 嘉一

× 田崎, 嘉一

ja 田崎, 嘉一

ja-Kana タサキ, ヨシカズ

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Yamamoto, Joe

× Yamamoto, Joe

en Yamamoto, Joe

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Omura, Tomohiro

× Omura, Tomohiro

en Omura, Tomohiro

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Sakaguchi, Tomoki

× Sakaguchi, Tomoki

en Sakaguchi, Tomoki

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Kimura, Norihisa

× Kimura, Norihisa

en Kimura, Norihisa

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Ohtaki, Koichi

× Ohtaki, Koichi

en Ohtaki, Koichi

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Ono, Takashi

× Ono, Takashi

en Ono, Takashi

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Suno, Manabu

× Suno, Manabu

en Suno, Manabu

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Asari, Masaru

× Asari, Masaru

en Asari, Masaru

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Ohkubo, Tomoko

× Ohkubo, Tomoko

en Ohkubo, Tomoko

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Noda, Toshihiro

× Noda, Toshihiro

en Noda, Toshihiro

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Awaya, Toshio

× Awaya, Toshio

en Awaya, Toshio

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Shimizu, Keiko

× Shimizu, Keiko

en Shimizu, Keiko

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Matsubara, Kazuo

× Matsubara, Kazuo

en Matsubara, Kazuo

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書誌情報 Neuroscience letters

巻 521, 号 1, p. 15-19, 発行日 2012-07-01
ISSN
収録物識別子タイプ PISSN
収録物識別子 0304-3940
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/j.neulet.2012.05.045
抄録
内容記述タイプ Abstract
内容記述 A series of oxicam non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to be neuroprotective against 1-methyl-4-phenyl pyridinium in human neuroblastoma SH-SY5Y cells via the phosphatidylinositol 3-kinase (PI3K)/Akt pathway independent of cyclooxygenase (COX) inhibition. The present study endeavored to establish this novel effect of meloxicam (MLX), an oxicam NSAID, in a mouse Parkinson's disease (PD) model using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Male C57BL/6 mice, which received MPTP (30 mg/kg/day; s.c.) for 5 consecutive days (chronic model) with 10-day follow-up saline administrations, showed significant motor dysfunction in the pole test due to reduced tyrosine hydroxylase (TH) protein levels in the brain on day 16 after MPTP/saline treatment. Daily coadministrations of MLX (10mg/kg/day; i.p.) and MPTP for the first 5 days and follow-up 10 days with MLX administrations alone (MPTP/MLX treatment) significantly ameliorated MPTP-induced behavioral abnormalities in mice. Concomitant decreases of TH protein levels in the striatum and midbrain of MPTP/MLX-treated mice were not only significantly (p<0.01 and p<0.05, respectively) ameliorated but phosphorylated Akt (pAkt473) expression in the midbrain was also significantly (p<0.01) increased in the midbrain when compared with MPTP/saline-treated mice. These results suggest that MLX, an oxicam NSAID, attenuated dopaminergic neuronal death in the experimental MPTP-PD model by maintenance of the Akt-signaling. Oxicam NSAIDs may serve as potential drugs for PD treatment via a novel mechanism of action.
言語 en
注記
内容記述タイプ Other
注記 Author
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内容記述タイプ Other
資源タイプ text
著者版フラグ
出版タイプ AM
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内容記述タイプ Other
内容記述 application/pdf
ID(XooNIps)
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田崎, 嘉一, Yamamoto, Joe, Omura, Tomohiro, Sakaguchi, Tomoki, Kimura, Norihisa, Ohtaki, Koichi, Ono, Takashi, Suno, Manabu, Asari, Masaru, Ohkubo, Tomoko, Noda, Toshihiro, Awaya, Toshio, Shimizu, Keiko, Matsubara, Kazuo, n.d., Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson&#39;s disease model: 15–19 p.

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