{"created":"2023-06-19T11:23:43.704722+00:00","id":4310,"links":{},"metadata":{"_buckets":{"deposit":"3514ca31-15b6-4839-b599-6a0ddf51ab59"},"_deposit":{"created_by":3,"id":"4310","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4310"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004310","sets":["7","7:24"]},"author_link":["13420","13421","13422","13423","13424","13425","13426","13427","13428","13429","13430","13431"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"19","bibliographicPageStart":"15","bibliographicVolumeNumber":"521","bibliographic_titles":[{"bibliographic_title":"Neuroscience letters"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A series of oxicam non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to be neuroprotective against 1-methyl-4-phenyl pyridinium in human neuroblastoma SH-SY5Y cells via the phosphatidylinositol 3-kinase (PI3K)/Akt pathway independent of cyclooxygenase (COX) inhibition. The present study endeavored to establish this novel effect of meloxicam (MLX), an oxicam NSAID, in a mouse Parkinson's disease (PD) model using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Male C57BL/6 mice, which received MPTP (30 mg/kg/day; s.c.) for 5 consecutive days (chronic model) with 10-day follow-up saline administrations, showed significant motor dysfunction in the pole test due to reduced tyrosine hydroxylase (TH) protein levels in the brain on day 16 after MPTP/saline treatment. Daily coadministrations of MLX (10mg/kg/day; i.p.) and MPTP for the first 5 days and follow-up 10 days with MLX administrations alone (MPTP/MLX treatment) significantly ameliorated MPTP-induced behavioral abnormalities in mice. Concomitant decreases of TH protein levels in the striatum and midbrain of MPTP/MLX-treated mice were not only significantly (p<0.01 and p<0.05, respectively) ameliorated but phosphorylated Akt (pAkt473) expression in the midbrain was also significantly (p<0.01) increased in the midbrain when compared with MPTP/saline-treated mice. These results suggest that MLX, an oxicam NSAID, attenuated dopaminergic neuronal death in the experimental MPTP-PD model by maintenance of the Akt-signaling. Oxicam NSAIDs may serve as potential drugs for PD treatment via a novel mechanism of action.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neulet.2012.05.045","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0304-3940","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"22617635"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"808"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"877"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田崎, 嘉一","creatorNameLang":"ja"},{"creatorName":"タサキ, ヨシカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Joe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Omura, Tomohiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakaguchi, Tomoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Norihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohtaki, Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suno, Manabu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13427","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asari, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13428","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Tomoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13429","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noda, Toshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Awaya, Toshio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13431","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Keiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsubara, Kazuo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"5065.pdf","filesize":[{"value":"182.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"5065.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4310/files/5065.pdf"},"version_id":"cd397312-75f0-47b6-bbc0-ecd3a6a5b358"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Oxicam","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-steroidal anti-inflammatory drugs (NSAIDs)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuroprotection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Parkinson’s disease (PD)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Akt","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-02-26"},"publish_date":"2013-02-26","publish_status":"0","recid":"4310","relation_version_is_last":true,"title":["Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T08:34:31.283090+00:00"}