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Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity
https://asahikawa-med.repo.nii.ac.jp/records/4309
https://asahikawa-med.repo.nii.ac.jp/records/4309d05d6b78-f6ee-4baa-85af-44e6caa32618
名前 / ファイル | ライセンス | アクション |
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5064.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2013-02-26 | |||||
タイトル | ||||||
タイトル | Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Oxicam | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Non-steroidal anti-inflammatory drug | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Neuroprotection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Parkinson’s disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Akt | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | 1-methyl-4-phenyl pyridinium | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
田崎, 嘉一
× 田崎, 嘉一× Yamamoto, Joe× Omura, Tomohiro× Noda, Toshihiro× Kamiyama, Naoya× Yoshida, Koichi× Satomi, Machiko× Sakaguchi, Tomoki× Asari, Masaru× Ohkubo, Tomoko× Shimizu, Keiko× Matsubara, Kazuo |
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著者 ローマ字 | ||||||
Tasaki, Yoshikazu | ||||||
書誌情報 |
European journal of pharmacology 巻 676, 号 1-3, p. 57-63, 発行日 2012-02-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0014-2999 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ejphar.2011.11.046 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the treatment of Parkinson's disease, potent disease-modifying drugs are still needed to halt progressive dopaminergic neurodegeneration. We have previously shown that meloxicam, an oxicam non-steroidal anti-inflammatory drug (NSAID), elicits a potent neuroprotective effect against 1-methyl-4-phenyl pyridinium (MPP(+))-induced toxicity in human dopaminergic SH-SY5Y neuroblastoma cells. This cyclooxygenase-independent neuroprotection of meloxicam is mediated via the phosphatidylinositol 3-kinase (PI3K)/Akt pathway; however, the specific chemical structure involved in inducing neuroprotection remains unresolved. In this study, we therefore investigated the structure-specific for eliciting the neuroprotective effect by examining a series of NSAIDs against MPP(+) toxicity in SH-SY5Y cells. Three oxicam-bearing NSAIDs showed potent neuroprotective effects, although none of the other 10 oxicam-nonbearing NSAIDs (3 salicylates, 6 coxibs and 1 polyphenol) or 3 piroxicam analogs (including ampiroxicam, a precursor of piroxicam) exerted any neuroprotection. Tenoxicam and piroxicam prevented MPP(+)-induced reduction of phosphorylated Akt levels in cells: a protective mechanism similar to that of meloxicam. Therefore, the oxicam structure was likely to be responsible for exhibiting the neuroprotection by sustaining survival-signaling in dopaminergic cells. The present results raise the possibility that the oxicam-bearing NSAIDs may serve as potential therapeutic drugs to retard or terminate progression of Parkinson's disease via a novel mechanism. | |||||
注記 | ||||||
内容記述タイプ | Other | |||||
注記 | Author | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
資源タイプ | text | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
22182582 | ||||||
閲覧数(XooNIps) | ||||||
783 | ||||||
ダウンロード数(XooNIps) | ||||||
1028 |