{"created":"2023-06-19T11:23:43.658089+00:00","id":4309,"links":{},"metadata":{"_buckets":{"deposit":"2b08c34d-8d16-4bcf-a33e-84a537120931"},"_deposit":{"created_by":3,"id":"4309","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4309"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004309","sets":["7","7:24"]},"author_link":["13408","13409","13410","13411","13412","13413","13414","13415","13416","13417","13418","13419"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-3","bibliographicPageEnd":"63","bibliographicPageStart":"57","bibliographicVolumeNumber":"676","bibliographic_titles":[{"bibliographic_title":"European journal of pharmacology"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the treatment of Parkinson's disease, potent disease-modifying drugs are still needed to halt progressive dopaminergic neurodegeneration. We have previously shown that meloxicam, an oxicam non-steroidal anti-inflammatory drug (NSAID), elicits a potent neuroprotective effect against 1-methyl-4-phenyl pyridinium (MPP(+))-induced toxicity in human dopaminergic SH-SY5Y neuroblastoma cells. This cyclooxygenase-independent neuroprotection of meloxicam is mediated via the phosphatidylinositol 3-kinase (PI3K)/Akt pathway; however, the specific chemical structure involved in inducing neuroprotection remains unresolved. In this study, we therefore investigated the structure-specific for eliciting the neuroprotective effect by examining a series of NSAIDs against MPP(+) toxicity in SH-SY5Y cells. Three oxicam-bearing NSAIDs showed potent neuroprotective effects, although none of the other 10 oxicam-nonbearing NSAIDs (3 salicylates, 6 coxibs and 1 polyphenol) or 3 piroxicam analogs (including ampiroxicam, a precursor of piroxicam) exerted any neuroprotection. Tenoxicam and piroxicam prevented MPP(+)-induced reduction of phosphorylated Akt levels in cells: a protective mechanism similar to that of meloxicam. Therefore, the oxicam structure was likely to be responsible for exhibiting the neuroprotection by sustaining survival-signaling in dopaminergic cells. The present results raise the possibility that the oxicam-bearing NSAIDs may serve as potential therapeutic drugs to retard or terminate progression of Parkinson's disease via a novel mechanism.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ejphar.2011.11.046","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0014-2999","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"22182582"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"783"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1028"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田崎, 嘉一","creatorNameLang":"ja"},{"creatorName":"タサキ, ヨシカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Joe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Omura, Tomohiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noda, Toshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamiyama, Naoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Satomi, Machiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakaguchi, Tomoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asari, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Tomoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsubara, Kazuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13419","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"5064.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"5064.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4309/files/5064.pdf"},"version_id":"7cf5b670-3ec9-4cb2-82f0-f61167ec3ece"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Oxicam","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-steroidal anti-inflammatory drug","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuroprotection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Parkinson’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Akt","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"1-methyl-4-phenyl pyridinium","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-02-26"},"publish_date":"2013-02-26","publish_status":"0","recid":"4309","relation_version_is_last":true,"title":["Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T08:35:15.319029+00:00"}