| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2013-02-20 |
| タイトル |
|
|
タイトル |
Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Lipin-1 |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Adipocyte |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Endoplasmic reticulum stress |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Obesity |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
高橋, 伸彦
Yoshizaki, Takayuki
Hiranaka, Natsumi
Suzuki, Takeshi
Yui, Tomoo
Akanuma, Masayasu
Kanazawa, Kaoru
Yoshida, Mika
Naito, Sumiyoshi
藤谷, 幹浩
高後, 裕
Ieko, Masahiro
|
| 著者 ローマ字 |
|
|
|
Fujiya, Mikihiro |
| 著者 ローマ字 |
|
|
|
en |
|
|
Kohgo, Yutaka |
| 著者 ローマ字 |
|
|
|
en |
| 書誌情報 |
Biochemical and biophysical research communications
巻 431,
号 1,
p. 25-30,
発行日 2013-02-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0006-291X |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.bbrc.2012.12.112 |
| PubMed番号 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
23291236 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Lipin-1 plays crucial roles in the regulation of lipid metabolism and cell differentiation in adipocytes. In obesity, adipose lipin-1 mRNA expression is decreased and positively correlated with systemic insulin sensitivity. Amelioration of the lipin-1 depletion might be improved dysmetabolism. Although some cytokines such as TNF-α and interleukin-1β reduces adipose lipin-1 expression, the mechanism of decreased adipose lipin-1 expression in obesity remains unclear. Recently, endoplasmic reticulum (ER) stress is implicated in the pathogenesis of obesity. Here we investigated the role of ER stress on the lipin-1 expression in 3T3-L1 adipocytes. We demonstrated that lipin-1 expression was suppressed by the treatment with ER stress inducers (tunicamycin and thapsigargin) at transcriptional level. We also showed that constitutive lipin-1 expression could be maintained by peroxisome proliferator-activated receptor-γ in 3T3-L1 adipocytes. Activation of peroxisome proliferator-activated receptor-γ recovered the ER stress-induced lipin-1 suppression. These results suggested that ER stress might be involved in the pathogenesis of obesity through lipin-1 depletion. |
|
言語 |
en |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
Author |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
|
|
出版タイプ |
AM |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
23291236 |
| 閲覧数(XooNIps) |
|
| ダウンロード数(XooNIps) |
|
|
|
1132 |
5054.pdf (644.2 kB)
