{"created":"2023-06-19T11:23:43.237120+00:00","id":4300,"links":{},"metadata":{"_buckets":{"deposit":"98671664-e57a-4a58-8b6d-fbe9b7a28ec8"},"_deposit":{"created_by":3,"id":"4300","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4300"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004300","sets":["7","7:24"]},"author_link":["13352","13353","13354","13355","13356","13357","13358","13359","13360","13361","13362","13363"],"control_number":"4300","item_1716186501932":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"23291236","subitem_relation_type_select":"PMID"}}]},"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"30","bibliographicPageStart":"25","bibliographicVolumeNumber":"431","bibliographic_titles":[{"bibliographic_title":"Biochemical and biophysical research communications"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lipin-1 plays crucial roles in the regulation of lipid metabolism and cell differentiation in adipocytes. In obesity, adipose lipin-1 mRNA expression is decreased and positively correlated with systemic insulin sensitivity. Amelioration of the lipin-1 depletion might be improved dysmetabolism. Although some cytokines such as TNF-α and interleukin-1β reduces adipose lipin-1 expression, the mechanism of decreased adipose lipin-1 expression in obesity remains unclear. Recently, endoplasmic reticulum (ER) stress is implicated in the pathogenesis of obesity. Here we investigated the role of ER stress on the lipin-1 expression in 3T3-L1 adipocytes. We demonstrated that lipin-1 expression was suppressed by the treatment with ER stress inducers (tunicamycin and thapsigargin) at transcriptional level. We also showed that constitutive lipin-1 expression could be maintained by peroxisome proliferator-activated receptor-γ in 3T3-L1 adipocytes. Activation of peroxisome proliferator-activated receptor-γ recovered the ER stress-induced lipin-1 suppression. These results suggested that ER stress might be involved in the pathogenesis of obesity through lipin-1 depletion.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2012.12.112","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"23291236"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1064"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1132"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Fujiya, Mikihiro"},{"subitem_text_language":"en","subitem_text_value":"Kohgo, Yutaka"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 伸彦","creatorNameLang":"ja"},{"creatorName":"タカハシ, ノブヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshizaki, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiranaka, Natsumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yui, Tomoo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akanuma, Masayasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13357","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanazawa, Kaoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13358","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Mika","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13359","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naito, Sumiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13360","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤谷, 幹浩","creatorNameLang":"ja"},{"creatorName":"フジヤ, ミキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13361","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高後, 裕","creatorNameLang":"ja"},{"creatorName":"コウゴ, ユタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13362","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ieko, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13363","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"5054.pdf","filesize":[{"value":"644.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"5054.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4300/files/5054.pdf"},"version_id":"16fd6235-225a-4991-9c2a-1246f59f4a58"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Lipin-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Adipocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endoplasmic reticulum stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Obesity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-02-20"},"publish_date":"2013-02-20","publish_status":"0","recid":"4300","relation_version_is_last":true,"title":["Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-08-09T06:54:39.516895+00:00"}