| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2013-01-29 |
| タイトル |
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タイトル |
Interference of deferasirox with assays for serum iron and serum unsaturated iron binding capacity during iron chelating therapy |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Deferasirox |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
serum iron |
| キーワード |
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|
主題Scheme |
Other |
|
キーワード |
unsaturated iron binding capacity (UIBC) |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
iron chelation |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
生田, 克哉
Ito, Satoshi
Tanaka, Hiroki
Sasaki, Katsunori
Torimoto, Yoshihiro
Fujiya, Mikihiro
Kohgo, Yutaka
|
| 書誌情報 |
Clinica Chimica Acta
巻 412,
号 23-24,
p. 2261-2266,
発行日 2011-11-01
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0009-8981 |
| DOI |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.cca.2011.08.020 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
|
内容記述 |
PMID：21884685 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background Deferasirox (DFX) is an oral iron chelator that is used worldwide for the treatment of iron overload. Although serum ferritin level is usually measured as a marker of the efficacy of DFX, we sometimes experienced unexplainable changes in other serum markers for iron. We hypothesized that photometric assays for serum iron (sFe) and unsaturated iron binding capacity (UIBC) might be affected by DFX. \nMethods Measurement of sFe and UIBC was performed using 4 different assay systems. The samples were prepared by adding 0–300 μM DFX to pooled human serum or 15 randomized human serum samples. In some experiments, DFX-iron complex (DFX-Fe) was prepared by mixing iron ammonium citrate solution and DFX solution. \nResults Measurement of sFe was influenced by DFX-Fe, while iron-free DFX showed no effect on the value of sFe; DFX-Fe was measured as sFe, undistinguishable from transferrin-bound iron. On the other hand, measurement of serum UIBC was influenced by DFX itself; DFX might have been bound to iron in the reagent used for the assay, leading to an increase in UIBC values. \nConclusions DFX affected the sFe and UIBC assay systems. We must be careful in observing these markers during iron chelation therapy with DFX. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Author |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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21884685 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
1193 |
4997.pdf (2.1 MB)
