{"created":"2023-06-19T11:23:41.174986+00:00","id":4259,"links":{},"metadata":{"_buckets":{"deposit":"872bd128-1092-4fed-9b55-00e439e3ba72"},"_deposit":{"created_by":3,"id":"4259","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4259"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004259","sets":["7","7:24"]},"author_link":["13153","13154","13155","13156","13157","13158","13159"],"control_number":"4259","item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"23-24","bibliographicPageEnd":"2266","bibliographicPageStart":"2261","bibliographicVolumeNumber":"412","bibliographic_titles":[{"bibliographic_title":"Clinica Chimica Acta"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：21884685","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background Deferasirox (DFX) is an oral iron chelator that is used worldwide for the treatment of iron overload. Although serum ferritin level is usually measured as a marker of the efficacy of DFX, we sometimes experienced unexplainable changes in other serum markers for iron. We hypothesized that photometric assays for serum iron (sFe) and unsaturated iron binding capacity (UIBC) might be affected by DFX. \\nMethods Measurement of sFe and UIBC was performed using 4 different assay systems. The samples were prepared by adding 0–300 μM DFX to pooled human serum or 15 randomized human serum samples. In some experiments, DFX-iron complex (DFX-Fe) was prepared by mixing iron ammonium citrate solution and DFX solution. \\nResults Measurement of sFe was influenced by DFX-Fe, while iron-free DFX showed no effect on the value of sFe; DFX-Fe was measured as sFe, undistinguishable from transferrin-bound iron. On the other hand, measurement of serum UIBC was influenced by DFX itself; DFX might have been bound to iron in the reagent used for the assay, leading to an increase in UIBC values. \\nConclusions DFX affected the sFe and UIBC assay systems. We must be careful in observing these markers during iron chelation therapy with DFX.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.cca.2011.08.020","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-8981","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"21884685"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1036"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1193"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"生田, 克哉","creatorNameLang":"ja"},{"creatorName":"イクタ, カツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13154","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Katsunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Torimoto, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujiya, Mikihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kohgo, Yutaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13159","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4997.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4997.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4259/files/4997.pdf"},"version_id":"94402ec1-f6ba-4f78-b8bf-63c825b8c386"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Deferasirox","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"serum iron","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"unsaturated iron binding capacity (UIBC)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"iron chelation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Interference of deferasirox with assays for serum iron and serum unsaturated iron binding capacity during iron chelating therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Interference of deferasirox with assays for serum iron and serum unsaturated iron binding capacity during iron chelating therapy","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-01-29"},"publish_date":"2013-01-29","publish_status":"0","recid":"4259","relation_version_is_last":true,"title":["Interference of deferasirox with assays for serum iron and serum unsaturated iron binding capacity during iron chelating therapy"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-29T02:51:48.099598+00:00"}