Item type |
学術雑誌論文 / Journal Article_02(1) |
公開日 |
2012-05-17 |
タイトル |
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言語 |
en |
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タイトル |
Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
著者 |
宮本, 正之
Ojima, H.
Iwasaki, M.
Shimizu, H.
Kokubu, A.
Hiraoka, N.
Kosuge, T.
Yoshikawa, D.
Kono, T.
Furukawa, H.
Shibata, T.
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書誌情報 |
British Journal of Cancer
巻 105,
号 1,
p. 131-138,
発行日 2011-06-01
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ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0007-0920 |
DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/bjc.2011.199 |
抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background:Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC. Patients and methods:One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Methigh and c-Metlow groups. Clinicopathological factors and outcomes were compared between the groups. C-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines. Results:The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Methigh expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. C-Methigh expression was significantly correlated with the 5-year survival rate for CC overall (P=0.0046) and for IHCC (P=0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Methigh expression was an independent predictor of poor overall and disease-free survival in patients with IHCC. Conclusions:c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC. |
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言語 |
en |
注記 |
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内容記述タイプ |
Other |
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注記 |
http://dx.doi.org/10.1038/bjc.2011.199 |
資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
ID(XooNIps) |
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21673683 |
閲覧数(XooNIps) |
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ダウンロード数(XooNIps) |
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1316 |