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Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma
https://asahikawa-med.repo.nii.ac.jp/records/4010
https://asahikawa-med.repo.nii.ac.jp/records/4010fc6b46e0-2f89-4bdb-a303-3c141f090144
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
4469.pdf (4.9 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2012-05-17 | |||||
| タイトル | ||||||
| タイトル | Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
宮本, 正之
× 宮本, 正之× Ojima, H.× Iwasaki, M.× Shimizu, H.× Kokubu, A.× Hiraoka, N.× Kosuge, T.× Yoshikawa, D.× Kono, T.× Furukawa, H.× Shibata, T. |
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| 書誌情報 |
British Journal of Cancer 巻 105, 号 1, p. 131-138, 発行日 2011-06-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0007-0920 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/bjc.2011.199 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background:Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC. Patients and methods:One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Methigh and c-Metlow groups. Clinicopathological factors and outcomes were compared between the groups. C-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines. Results:The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Methigh expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. C-Methigh expression was significantly correlated with the 5-year survival rate for CC overall (P=0.0046) and for IHCC (P=0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Methigh expression was an independent predictor of poor overall and disease-free survival in patients with IHCC. Conclusions:c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC. | |||||
| 言語 | en | |||||
| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://dx.doi.org/10.1038/bjc.2011.199 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 21673683 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 1011 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 1316 | |||||
