{"created":"2023-06-19T11:23:28.057077+00:00","id":4010,"links":{},"metadata":{"_buckets":{"deposit":"5b47db4c-ccf7-4f94-9fe3-187ac1a029bc"},"_deposit":{"created_by":3,"id":"4010","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4010"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004010","sets":["7","7:24"]},"author_link":["12116","12117","12118","12119","12120","12121","12122","12123","12124","12125","12126"],"control_number":"4010","item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"138","bibliographicPageStart":"131","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"British Journal of Cancer"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC. Patients and methods:One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Methigh and c-Metlow groups. Clinicopathological factors and outcomes were compared between the groups. C-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines. Results:The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Methigh expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. C-Methigh expression was significantly correlated with the 5-year survival rate for CC overall (P=0.0046) and for IHCC (P=0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Methigh expression was an independent predictor of poor overall and disease-free survival in patients with IHCC. Conclusions:c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"http://dx.doi.org/10.1038/bjc.2011.199","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/bjc.2011.199","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0007-0920","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"21673683"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1011"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1316"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮本, 正之","creatorNameLang":"ja"},{"creatorName":"ミヤモト, マサシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"12116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ojima, H.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwasaki, M.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, H.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kokubu, A.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiraoka, N.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kosuge, T.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshikawa, D.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kono, T.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, H.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12125","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, T.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12126","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4469.pdf","filesize":[{"value":"4.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4469.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4010/files/4469.pdf"},"version_id":"f6a4930b-c872-4d81-80e8-f2b3eef0c3f3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-05-17"},"publish_date":"2012-05-17","publish_status":"0","recid":"4010","relation_version_is_last":true,"title":["Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-31T04:46:42.300388+00:00"}