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Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes
https://asahikawa-med.repo.nii.ac.jp/records/4003
https://asahikawa-med.repo.nii.ac.jp/records/4003d4bd1059-73c5-4b41-bad1-54e50d02c1cd
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||
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公開日 | 2012-05-17 | |||||||
タイトル | ||||||||
タイトル | Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes | |||||||
言語 | en | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
高橋, 伸彦
× 高橋, 伸彦× Yoshizaki, Takayuki× Hiranaka, Natsumi× Suzuki, Takeshi× Yui, Tomoo× Akanuma, Masayasu× Oka, Kazuya× Kanazawa, Kaoru× Yoshida, Mika× Naito, Sumiyoshi× Fujiya, Mikihiro× Kohgo, Yutaka× Ieko, Masahiro
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書誌情報 |
Biochemical and Biophysical Research Communications 巻 415, 号 1, p. 200-205, 発行日 2011-11-01 |
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ISSN | ||||||||
収録物識別子タイプ | PISSN | |||||||
収録物識別子 | 0006-291X | |||||||
DOI | ||||||||
識別子タイプ | DOI | |||||||
関連識別子 | 10.1016/j.bbrc.2011.10.060 | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Lipin-1 plays a crucial role in the regulation of lipid metabolism and cell differentiation in adipocytes. Expression of adipose lipin-1 is reduced in obesity, and metabolic syndrome. However, the significance of this reduction remains unclear. This study investigated if and how reduced lipin-1 expression affected metabolism. We assessed mRNA expression levels of various genes related to adipocyte metabolism in lipin-1-depleted 3T3-L1 adipocytes by introducing its specific small interfering RNA. In lipin-1-depleted adipocytes, mRNA and protein expression levels of monocyte chemoattractant protein-1 (MCP-1) were significantly increased, although the other genes tested were not altered. The conditioned media from the cells promoted monocyte chemotaxis. The increase in MCP-1 expression was prevented by treatment with quinazoline or salicylate, inhibitors of nuclear factor-κB activation. Because MCP-1 is related to adipose inflammation and systemic insulin resistance, these results suggest that a reduction in adipose lipin-1 in obesity may exacerbate adipose inflammation and metabolism. | |||||||
言語 | en | |||||||
注記 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | http://dx.doi.org/10.1016/j.bbrc.2011.10.060 | |||||||
資源タイプ | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | text | |||||||
著者版フラグ | ||||||||
出版タイプ | AM | |||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
ID(XooNIps) | ||||||||
値 | 22033411 | |||||||
閲覧数(XooNIps) | ||||||||
値 | 994 | |||||||
ダウンロード数(XooNIps) | ||||||||
値 | 978 |