| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2012-05-17 |
| タイトル |
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|
タイトル |
Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
高橋, 伸彦
Yoshizaki, Takayuki
Hiranaka, Natsumi
Suzuki, Takeshi
Yui, Tomoo
Akanuma, Masayasu
Oka, Kazuya
Kanazawa, Kaoru
Yoshida, Mika
Naito, Sumiyoshi
Fujiya, Mikihiro
Kohgo, Yutaka
Ieko, Masahiro
|
| 書誌情報 |
Biochemical and Biophysical Research Communications
巻 415,
号 1,
p. 200-205,
発行日 2011-11-01
|
| ISSN |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0006-291X |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.bbrc.2011.10.060 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Lipin-1 plays a crucial role in the regulation of lipid metabolism and cell differentiation in adipocytes. Expression of adipose lipin-1 is reduced in obesity, and metabolic syndrome. However, the significance of this reduction remains unclear. This study investigated if and how reduced lipin-1 expression affected metabolism. We assessed mRNA expression levels of various genes related to adipocyte metabolism in lipin-1-depleted 3T3-L1 adipocytes by introducing its specific small interfering RNA. In lipin-1-depleted adipocytes, mRNA and protein expression levels of monocyte chemoattractant protein-1 (MCP-1) were significantly increased, although the other genes tested were not altered. The conditioned media from the cells promoted monocyte chemotaxis. The increase in MCP-1 expression was prevented by treatment with quinazoline or salicylate, inhibitors of nuclear factor-κB activation. Because MCP-1 is related to adipose inflammation and systemic insulin resistance, these results suggest that a reduction in adipose lipin-1 in obesity may exacerbate adipose inflammation and metabolism. |
|
言語 |
en |
| 注記 |
|
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内容記述タイプ |
Other |
|
注記 |
http://dx.doi.org/10.1016/j.bbrc.2011.10.060 |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
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|
22033411 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
978 |
4462.pdf (567.8 kB)
